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Glucaric acids from Leonurus japonicus.

Jianshuang Jiang1, Yixiu Li2, Ziming Feng1

  • 1Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing 100050, People's Republic of China.

Fitoterapia
|November 4, 2015
PubMed
Summary
This summary is machine-generated.

Three novel glucaric acids from Leonurus japonicus Houtt. were identified. Compound 2 demonstrated moderate hepatoprotection, while compounds 1-3 showed no significant cytotoxic activity in vitro.

Keywords:
Cytotoxicity activitiesGlucaric acidHepatoprotection activityLeonurus japonicus Houtt

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Area of Science:

  • Natural Product Chemistry
  • Pharmacology

Background:

  • Leonurus japonicus Houtt. is a traditional medicinal herb.
  • Investigating novel bioactive compounds from natural sources is crucial for drug discovery.

Purpose of the Study:

  • To isolate and characterize new glucaric acid derivatives from Leonurus japonicus Houtt.
  • To evaluate the hepatoprotective and cytotoxic activities of the isolated compounds.

Main Methods:

  • Isolation of compounds using chromatographic techniques.
  • Structure elucidation via UV, IR, HR-ESI-MS, and NMR spectroscopy.
  • In vitro assays for hepatoprotection and cytotoxicity.

Main Results:

  • Three new glucaric acids, compounds 1-3, were successfully isolated and characterized.
  • Compound 2 exhibited moderate hepatoprotection with a 74% cell survival rate at 10(-5)mol/L.
  • Compounds 1-3 displayed no significant cytotoxic activity against HCT-8, Bel-7402, BGC-823, A-549, and A2780 cell lines.

Conclusions:

  • Novel glucaric acid derivatives were identified from Leonurus japonicus Houtt.
  • Compound 2 shows potential as a hepatoprotective agent.
  • The isolated compounds lack significant in vitro cytotoxicity, suggesting a favorable safety profile.