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Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
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Relation of ambulatory blood pressure measurement and cognitive functions in hypertensive elderly patients

D Kececi Savan1, M Cengiz1, H Yavuzer2

  • 1Department of Internal Medicine, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Aging Clinical and Experimental Research
|November 4, 2015
PubMed

Insights

Blood pressure regulation, not dipping status, is linked to cognitive function in elderly hypertensive patients. Further subgroup analyses are needed to understand hypertension and cognitive decline.

Area of Science:

  • Geriatric Medicine
  • Cardiology
  • Neurology

Background:

  • Hypertension is a significant risk factor for dementia and cardiovascular disease.
  • Sustained hypertension exacerbates the risk of cognitive decline.
  • Elderly hypertensive patients without other cognitive-impairing conditions were the focus.

Purpose of the Study:

  • To investigate the relationship between 24-hour ambulatory blood pressure monitoring (ABPM) and cognitive function.
  • To assess cognitive performance in elderly hypertensive individuals based on blood pressure regulation and dipping status.

Main Methods:

  • Ninety-one hypertensive patients over 60 were included.
  • Standardized mini-mental test (sMMT) and geriatric depression scale (GDS) were administered.
  • Patients were categorized into dipper/nondipper and regulated/nonregulated groups for sMMT score comparison.

Main Results:

  • No significant difference in sMMT scores was found between dipper and nondipper groups.
  • A moderate association was observed between hypertension regulation and cognitive function (r=0.333, p=0.001).

Conclusions:

  • Tension regulation, not the nondipper status, is associated with cognitive function in elderly primary hypertensive patients.
  • Findings highlight the need for subgroup analyses in hypertension and cognitive function studies.
Abstract

Keywords:
Ambulatory blood pressure monitoringCognitive functionDipperGeriatric depression scaleHypertensionStandardized mini mental test

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