Enteric glia: A new player in inflammatory bowel diseases
E Capoccia1, C Cirillo2, S Gigli1
1Department of Physiology and Pharmacology 'Vittorio Erspamer', University Sapienza of Rome, P.le Aldo Moro 5, 00185, Rome, Italy.
International Journal of Immunopathology and Pharmacology
|November 4, 2015
Summary
Enteric glial cells (EGCs) contribute to inflammatory bowel diseases (IBD) by releasing S100B protein. Modulating EGCs offers a novel therapeutic strategy for IBD treatment.
Area of Science:
- Neurogastroenterology
- Immunology
- Gastroenterology
Background:
- Inflammatory bowel diseases (IBD) involve more cell types than previously known, including enteric glial cells (EGCs).
- EGCs, analogous to astrocytes in the central nervous system, possess neurotrophic and neuro-immunomodulatory functions.
- These cells play a role in maintaining gut homeostasis and modulating enteric neuronal activity.
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