Defining the Urological Chronic Pelvic Pain Syndromes
1Consultant in Urological Pain Medicine, University College, London.
Reviews in Pain
|November 4, 2015
Summary
Urogenital pain (UGP) mechanisms are better understood, shifting focus from organ issues to central neuroplasticity. Management now requires multidisciplinary and interdisciplinary approaches for effective treatment.
Area of Science:
- Neuroscience
- Urology
- Pain Management
Background:
- Urogenital pain (UGP) has historically been attributed to 'end-organ' dysfunction.
- Recent research suggests a shift in understanding UGP mechanisms.
Purpose of the Study:
- To elucidate the current understanding of urogenital pain mechanisms.
- To highlight the evolving theoretical framework for UGP.
- To emphasize the implications for clinical management strategies.
Main Methods:
- The content is derived from an international symposium hosted by the National Institutes of Health.
- Discussions focused on the neurobiological underpinnings of UGP.
- Expert consensus and review of emerging evidence formed the basis of the findings.
Main Results:
- A paradigm shift in understanding UGP mechanisms is evident.
- Central neuroplasticity is increasingly recognized as a key factor in UGP.
- The 'end-organ' theory is being superseded by neuroplasticity models.
Conclusions:
- Current understanding of urogenital pain mechanisms favors a central neuroplasticity theory.
- Effective management of UGP necessitates a multidisciplinary and interdisciplinary approach.
- Future research and clinical practice should integrate these evolving concepts.
Related Concept Videos
Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations
689
Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...
689
Chronic Bowel Disorders: Introduction
913
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
913
Chronic Pancreatitis I: Introduction
890
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
890
Disorders of the Urinary System
1.9K
The urinary system is responsible for eliminating waste and excess fluids from the body. However, disorders of the urinary system can arise due to various reasons like infections, stress, age, congenital abnormalities, and lifestyle.
Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...
Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...
1.9K
Urinary Tract Infection II: Pathophysiology
1.2K
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
1.2K
Acute Pyelonephritis II: Diagnostic Studies and Management
649
Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
649


