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Linezolid induced retinopathy.

Dae Hyun Park1, Tae Kwann Park1, Young-Hoon Ohn1

  • 1Department of Ophthalmology, Soonchunhyang University Bucheon Hospital, #170 Jomaru-ro, Wonmi-gu, Bucheon, 420-767, Korea.

Documenta Ophthalmologica. Advances in Ophthalmology
|November 4, 2015
PubMed
Summary

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Linezolid treatment can cause vision loss due to retinopathy, not just optic neuropathy. Multifocal electroretinogram (mfERG) revealed cone dysfunction, which improved after discontinuing linezolid.

Area of Science:

  • Ophthalmology
  • Pharmacology
  • Neuroscience

Background:

  • Linezolid is an antibiotic used for drug-resistant tuberculosis.
  • Optic neuropathy is a known side effect of linezolid.
  • Linezolid-related retinopathy has not been previously investigated.

Observation:

  • A 61-year-old male treated with linezolid for 5 months developed painless bilateral vision loss.
  • Clinical examination showed decreased visual acuity, defective color vision, and visual field defects.
  • Optical coherence tomography (OCT) revealed mild optic disc swelling.

Findings:

  • Multifocal electroretinogram (mfERG) demonstrated depressed central amplitudes in both eyes, suggesting cone dysfunction.
  • Cessation of linezolid led to improved visual acuity, color vision, and visual fields.
Keywords:
LinezolidMultifocal electroretinogramOptic neuropathyRetinopathy

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  • OCT and mfERG findings also showed improvement after linezolid withdrawal.

    • Implications:

    • This case suggests linezolid may cause retinopathy, distinct from optic neuropathy.
    • mfERG is a valuable tool for diagnosing linezolid-induced retinopathy.
    • Ophthalmologists should consider retinopathy in patients on linezolid experiencing visual disturbances.