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Updated: Mar 30, 2026

Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice
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Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice

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The postnatal morbidity associated with second-trimester miscarriage.

Aoife Morris1, Sarah Meaney2, Niamh Spillane1

  • 1a Department of Obstetrics & Gynaecology , Cork University Maternity Hospital , Cork , Ireland and.

The Journal of Maternal-Fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
|November 4, 2015
PubMed
Summary
This summary is machine-generated.

Second-trimester miscarriage management presents distinct complications. Preterm premature rupture of membranes (PPROM) cases showed higher risks of antibiotic use and readmission compared to intrauterine fetal demise (IUFD).

Keywords:
Miscarriagemorbiditypostnatalsecond-trimester

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Area of Science:

  • Obstetrics and Gynecology
  • Reproductive Medicine
  • Maternal-Fetal Medicine

Background:

  • Second-trimester miscarriage is a distinct obstetric event.
  • Management and delivery can be associated with significant complications.
  • Understanding these complications is crucial for clinical practice.

Purpose of the Study:

  • To detail the complications and their incidence in second-trimester miscarriages.
  • To analyze factors associated with these complications.
  • To inform clinical management strategies.

Main Methods:

  • Retrospective cohort study of 181 second-trimester pregnancy losses (14-23 weeks gestation).
  • Review of medical records to identify complications.
  • Logistic regression to assess associations with clinical presentation and management.

Main Results:

  • Mean gestation of loss was 18 weeks.
  • Intrauterine fetal demise (IUFD) accounted for 64.6% of losses.
  • Preterm premature rupture of membranes (PPROM) cases had higher odds of requiring antibiotics (OR 13.75) and readmission (OR 4.15) compared to IUFD.

Conclusions:

  • Second-trimester miscarriage represents a distinct cohort with high morbidity rates.
  • Management requires medical intervention, highlighting the need for awareness of associated risks.
  • Findings should guide future clinical practice and patient care.