Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

2.3K
The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
2.3K
Blood and Nerve Supply to the Bones01:29

Blood and Nerve Supply to the Bones

14.6K
Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
14.6K
Skeletal Muscle Relaxants: Adverse Effects01:21

Skeletal Muscle Relaxants: Adverse Effects

1.1K
Skeletal muscle relaxants are widely used for muscle paralysis and relieving pain following any muscle injury or stiffness. However, depending on the drug type, they can have adverse effects that range from mild to severe. Usually, nondepolarizing neuromuscular blockers have minimal side effects. For example, drugs like d-tubocurarine, cisatracurium, and rocuronium cause hypotension, whereas drugs like baclofen, when stopped abruptly, can lead to the recurrence of spastic conditions.
Unlike...
1.1K
Skeletal Muscle Relaxants: Therapeutic Uses01:31

Skeletal Muscle Relaxants: Therapeutic Uses

1.1K
Skeletal muscle relaxants are used to relax muscle tone and alleviate painful muscle contractions. However, the choice of skeletal muscle relaxants depends on the duration of the surgical procedure in order to minimize potential side effects. Skeletal muscle relaxants like neuromuscular blocking agents [NMBAs] are commonly employed as adjuvants alongside general anesthetics in clinical settings. NMBAs are also used to maintain controlled ventilation during surgery of the larynx or pharynx...
1.1K
The Functions of the Skeletal System01:22

The Functions of the Skeletal System

6.8K
The most apparent functions of the skeletal system are support, protection, and movement. However, bone tissue also performs several other critical metabolic functions. For one, the bone matrix acts as a reservoir for a number of minerals important to the functioning of the body, especially calcium and phosphorus. These minerals, present in the bone tissue, can be released back into the bloodstream when required. Calcium ions, for example, are essential for muscle contractions and controlling...
6.8K
Classification of Skeletal Muscle Relaxants01:28

Classification of Skeletal Muscle Relaxants

3.3K
Skeletal muscle relaxants are a group of drugs that can reduce muscle stiffness and induce temporary paralysis to relieve pain. These agents can act centrally to reduce muscle tone or spasms in painful conditions such as multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), or spinal injuries; they are called antispasmodics or spasmolytics.
Peripherally acting skeletal muscle relaxants interfere with the neurotransmission at the neuromuscular end plate to induce paralysis during...
3.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The work and vocational advice intervention for adults in full or part-time employment: a synopsis of the WAVE feasibility study and RCT.

Health technology assessment (Winchester, England)·2026
Same author

From research to practice: barriers to implementation of psychologically informed practice in the sports setting.

British journal of sports medicine·2026
Same author

Addition of early vocational advice to usual primary care on sickness absence in employed adults: exploratory findings from the discontinued WAVE Randomised Controlled Trial.

Health technology assessment (Winchester, England)·2026
Same author

Can vocational advice be delivered in primary care? The Work And Vocational advicE (WAVE) mixed method single arm feasibility study.

BMJ open·2025
Same author

Trajectories of Work Absence in England due to a Musculoskeletal or Mental Health Condition: An Electronic Health Record Cohort Study.

Journal of occupational rehabilitation·2025
Same author

Effectiveness of two vocational interventions on sickness absence and costs for people with musculoskeletal disorders: 12 months results from the MI-NAV multi-arm randomized trial.

Scandinavian journal of work, environment & health·2025
Same journal

Non-Obstetric Pain in Pregnancy.

Reviews in pain·2015
Same journal

Neuroimaging of Visceral Pain.

Reviews in pain·2015
Same journal

Editorial.

Reviews in pain·2015
Same journal

Editorial.

Reviews in pain·2015
Same journal

Recent Advancements in Temporomandibular Disorders (TMDs).

Reviews in pain·2015
Same journal

Chronic Pain and Icebergs.

Reviews in pain·2015
See all related articles

Related Experiment Video

Updated: Mar 30, 2026

Author Spotlight: Fu's Subcutaneous Needling for Knee Osteoarthritis Pain
07:19

Author Spotlight: Fu's Subcutaneous Needling for Knee Osteoarthritis Pain

Published on: March 24, 2023

6.4K

Working with Musculoskeletal Pain.

Rhiannon Buck1, Gwenllian Wynne-Jones2, Alice Varnava1

  • 1Centre for Psychosocial and Disability Research, School of Psychology, Cardiff University.

Reviews in Pain
|November 4, 2015
PubMed
Summary
This summary is machine-generated.

Chronic pain significantly impacts work, leading to absence and disability. A bio-psychosocial approach and whole systems interventions are crucial for work retention and rehabilitation.

More Related Videos

Spontaneous and Evoked Measures of Pain in Murine Models of Monoarticular Knee Pain
08:03

Spontaneous and Evoked Measures of Pain in Murine Models of Monoarticular Knee Pain

Published on: February 22, 2019

9.0K
Biomechanical Changes Related to Low Back Pain: An Innovative Tool for Movement Pattern Assessment and Treatment Evaluation in Rehabilitation
06:28

Biomechanical Changes Related to Low Back Pain: An Innovative Tool for Movement Pattern Assessment and Treatment Evaluation in Rehabilitation

Published on: December 13, 2024

1.6K

Related Experiment Videos

Last Updated: Mar 30, 2026

Author Spotlight: Fu's Subcutaneous Needling for Knee Osteoarthritis Pain
07:19

Author Spotlight: Fu's Subcutaneous Needling for Knee Osteoarthritis Pain

Published on: March 24, 2023

6.4K
Spontaneous and Evoked Measures of Pain in Murine Models of Monoarticular Knee Pain
08:03

Spontaneous and Evoked Measures of Pain in Murine Models of Monoarticular Knee Pain

Published on: February 22, 2019

9.0K
Biomechanical Changes Related to Low Back Pain: An Innovative Tool for Movement Pattern Assessment and Treatment Evaluation in Rehabilitation
06:28

Biomechanical Changes Related to Low Back Pain: An Innovative Tool for Movement Pattern Assessment and Treatment Evaluation in Rehabilitation

Published on: December 13, 2024

1.6K

Area of Science:

  • Occupational Health
  • Pain Management
  • Rehabilitation Science

Background:

  • Pain significantly affects work through presenteeism, sickness absence, and long-term incapacity.
  • Long-term work absence is linked to adverse outcomes like poverty, social exclusion, and reduced well-being.

Purpose of the Study:

  • To highlight the necessity of a bio-psychosocial framework for understanding pain-related work disability.
  • To emphasize the importance of interventions across multiple levels for pain management and work retention.

Main Methods:

  • Review and synthesis of literature on pain, work, and rehabilitation.
  • Analysis of the impact of pain on work capacity and return-to-work processes.

Main Results:

  • A bio-psychosocial approach is essential for addressing pain-related disability and work incapacity.
  • Return to work can positively influence recovery for individuals with musculoskeletal pain.
  • Interventions targeting clinical, worker, workplace, and system levels are effective.

Conclusions:

  • A comprehensive, whole systems approach to pain management is needed, prioritizing work retention alongside rehabilitation.
  • Integrating work retention strategies into pain management is vital for improving outcomes.