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Elevated plasma aldosterone is an independent risk factor for erectile dysfunction in men
Fei Wu1, Shanhua Mao1, Tianfang Yu2
1Department of Urology, Huashan Hospital, Fudan University, 12 Central Urumqi Rd, Shanghai, 200040, People's Republic of China.
World Journal of Urology
|November 4, 2015
Summary
Elevated aldosterone is an independent risk factor for erectile dysfunction (ED). This finding suggests aldosterone may link ED and cardiovascular disease (CVD).
Area of Science:
- Endocrinology
- Cardiology
- Urology
Background:
- Erectile dysfunction (ED) and cardiovascular disease (CVD) share common risk factors.
- Aldosterone is an independent risk factor for CVD and is increasingly linked to ED.
Purpose of the Study:
- To investigate the relationship between plasma aldosterone levels and erectile dysfunction.
- To determine if aldosterone is an independent risk factor for ED.
Main Methods:
- 287 participants (18-84 years) were recruited, with 217 diagnosed with ED using the International Index of Erectile Function 5 (IIEF-5) scores.
- Participants were categorized into control and three ED severity groups (mild, moderate, severe).
- Key biochemical markers, including adrenal hormones, were compared between groups.
Main Results:
- Plasma aldosterone levels were significantly higher in the ED group compared to controls (P < 0.05).
- Aldosterone was identified as an independent risk factor for ED (OR 1.011, P = 0.004).
- Receiver operating characteristic (ROC) analysis indicated aldosterone's diagnostic potential for ED.
Conclusions:
- Elevated plasma aldosterone concentration is an independent risk factor for erectile dysfunction.
- Aldosterone, known for vascular injury, may represent a link between ED and CVD.
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