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Peripheral Ulcerative Keratitis with Pyoderma Gangrenosum.

Adrián Imbernón-Moya1, Elena Vargas-Laguna1, Antonio Aguilar1

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Case Reports in Dermatological Medicine
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Pyoderma gangrenosum, a rare skin condition, can affect the eye, causing peripheral ulcerative keratitis. Early diagnosis and treatment with systemic steroids and cyclosporine A led to successful outcomes in a reported case.

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Area of Science:

  • Dermatology
  • Ophthalmology

Background:

  • Pyoderma gangrenosum is a rare, noninfective, necrotizing ulcerative skin disease with unknown etiology.
  • Ophthalmic involvement, though uncommon, can manifest as scleral, corneal, or orbital issues.
  • Peripheral ulcerative keratitis (PUK) involves peripheral corneal destruction, often linked to autoimmune diseases.

Purpose of the Study:

  • To highlight the association between pyoderma gangrenosum and peripheral ulcerative keratitis.
  • To emphasize the importance of including pyoderma gangrenosum in the differential diagnosis of PUK.
  • To present a case of successful management of ocular pyoderma gangrenosum.

Main Methods:

  • A case study of a 70-year-old female patient with pyoderma gangrenosum and peripheral ulcerative keratitis.
  • Review of literature on ophthalmic manifestations of pyoderma gangrenosum.
  • Treatment involved systemic steroids and cyclosporine A.

Main Results:

  • The patient presented with pyoderma gangrenosum and peripheral ulcerative keratitis in the left eye.
  • Both skin lesions and peripheral keratitis showed a successful response to the prescribed treatment.
  • No specific cause for the pyoderma gangrenosum was identified.

Conclusions:

  • Pyoderma gangrenosum is a potential cause of peripheral ulcerative keratitis and should be considered in its differential diagnosis.
  • Prompt recognition and appropriate treatment, including systemic steroids and immunosuppressants like cyclosporine A, can significantly improve patient outcomes.
  • Ophthalmic involvement in pyoderma gangrenosum, while rare, necessitates specialized dermatological and ophthalmological management.