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Intense Walking Exercise Affects Serum IGF-1 and IGFBP3.

TaeHo Kim1, Jae Seung Chang1, Hanul Kim1

  • 1Department of Physiology and Center for Exercise Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.

Journal of Lifestyle Medicine
|November 4, 2015
PubMed
Summary

A 100 km walk significantly impacts Insulin-like Growth Factor (IGF-1) and IGF Binding Protein 3 (IGFBP3) levels. This intense exercise also altered key metabolic markers, including cholesterol and glucose.

Keywords:
IGF-1IGFBP3Walkathon

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Area of Science:

  • Endocrinology
  • Exercise Physiology
  • Metabolic Health

Background:

  • Insulin-like growth factor (IGF-1) is linked to chronic diseases like diabetes and cardiovascular conditions.
  • Previous research on exercise and IGF-1 levels shows inconsistent findings.
  • The impact of prolonged walking on IGF-1, IGFBP3, and their ratio requires further investigation.

Purpose of the Study:

  • To determine the effect of a 100 km walking exercise on serum IGF-1 and IGFBP3 levels.
  • To analyze changes in the IGF-1/IGFBP3 ratio following a 100 km walk.
  • To investigate alterations in metabolic-related blood parameters post-intense walking.

Main Methods:

  • 14 healthy middle-aged men participated in the study.
  • Body composition and metabolic markers (lipids, glucose, renal/hepatic function) were measured before and after a 100 km walk.
  • Serum IGF-1 and IGFBP3 levels were analyzed, and the IGF-1/IGFBP3 ratio was calculated.

Main Results:

  • Significant changes were observed in participants' metabolic profiles after the 100 km walk.
  • Serum levels of IGF-1 and IGFBP3 significantly decreased post-exercise.
  • The IGF-1/IGFBP3 ratio also showed a significant decrease after the walking race.

Conclusions:

  • Intense walking exercise demonstrably affects serum IGF-1 and IGFBP3 concentrations.
  • Metabolic biomarkers, including high-density cholesterol, glucose, and triglycerides, are altered by prolonged walking.
  • The study highlights the physiological impact of endurance walking on endocrine and metabolic factors.