Related Experiment Video
Updated: Mar 30, 2026
Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model
Published on: November 4, 2025
Cranial base characteristics in anteroposterior malocclusions: A meta-analysis
Aixiu Gong1, Jing Li2, Zhendong Wang3
1a MD Student, Department of Orthodontics, School of Stomatology, Nanjing Medical University, Nanjing, China; Attending Physician, Department of Stomatology, Nanjing Children's Hospital, Affiliated with Nanjing Medical University, Nanjing, China.
Objective:
To investigate cranial base characteristics in malocclusions with sagittal discrepancies.
Materials And Methods:
An electronic search was performed in PubMed, Embase, Web of Science, and the Cochrane Library. A fixed- or random-effect model was applied to calculate weighted mean difference with 95% confidence intervals (CIs) according to statistical heterogeneity. Outcome measures were anterior, posterior, and total cranial base length and cranial base angle. Sensitivity analysis and publication bias were conducted.
Results:
Twenty studies that together included 1121 Class I, 1051 Class II, and 730 Class III cases qualified for the final analysis. Class III malocclusion demonstrated significantly reduced anterior (95% CI: -1.74, -0.53; P < .001 vs Class I; 95% CI: -3.30, -2.09; P < .001 vs Class II) and total cranial base length (95% CI: -3.33, -1.36; P < .001 vs Class I; 95% CI: -7.38, -4.05; P < .001 vs Class II). Further, Class II patients showed significantly greater anterior and total cranial base length than did Class I patients (95% CI: 0.51, 1.87; P < .001 for SN; 95% CI: 2.20, 3.30; P < .001 for NBa). Cranial base angle was significantly smaller in Class III than in Class I (95% CI: -3.14, -0.93; P < .001 for NSBa; 95% CI: -2.73, -0.68; P = .001 for NSAr) and Class II malocclusions (95% CI: -5.73, -1.06; P = .004 for NSBa; 95% CI: -6.11, -1.92; P < .001 for NSAr) and greater in Class II than in Class I malocclusions (95% CI: 1.38, 2.38; P < .001 for NSBa).
Conclusions:
This meta-analysis showed that anterior and total cranial base length and cranial base angle were significantly smaller in Class III malocclusion than in Class I and Class II malocclusions, and that they were greater in Class II subjects compared to controls.
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