[The kinetics of bacterial killing by fluctuating concentrations of antibiotics]

Differences in kill kinetics and the regrowth pattern of bacteria under the influence of various antibiotics are frequently not represented by their MIC values. The area under the concentration curve represents antimicrobial activity more accurately than the peak concentration. Readministration of antibiotics should occur prior to bacterial regrowth for optimal efficacy. When administering combinations of antibiotics non-simultaneous dosing is superior to simultaneous administration.