[Personal experience with immunosuppression with cyclosporin A in kidney transplantation]

Nonspecific immunosuppressants have nonselective impacts, attacking the global human immune system. By such impacts, it is considered that selective immune response on implanted graft will be reduced. That would be a general therapy without a specific target, with toxic side effects. The application of nonspecific immunosuppression in transplantology has been used within well known immunosuppressive protocols, such as Minnesota and Massachusetts General protocol and many others. All those protocols are considered to be nonflexible schemes which are used in order to prevent the global immune response in recipients. Those schemes do not take into consideration the specificity and sensitivity of the recipients' body in each specific case. It is not necessary to emphasize that in period of the exclusive use of nonspecific immunosuppressants the death rate was higher when caused by the side effects of those. It is still early according to our experience, for definite conclusions regarding the advantages of cyclosporin suppression above the classic one.