[Left heart hypertrophy in arterial hypertension in relation to hemodynamic and humoral factors]
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C Punzengruber1, B Stanek, K Silberbauer
1II. Medizinischen Universitätsklinik, Ludwig-Boltzmann-Institut für klinische Endokrinologie.
Insights
In patients with arterial hypertension, left ventricular hypertrophy is primarily linked to elevated systolic blood pressure and age. Hemodynamic and humoral factors showed no significant correlation with left ventricular mass in this study.
Area of Science:
- Cardiology
- Hypertension Research
- Echocardiography
Context:
- Arterial hypertension can lead to left ventricular hypertrophy (LVH).
- Hemodynamic and humoral factors are potential contributors to LVH development.
- Understanding LVH determinants is crucial for managing hypertensive heart disease.
Purpose:
- To investigate the relationship between left ventricular mass and hemodynamic/humoral parameters in patients with long-standing hypertension.
- To identify key factors influencing left ventricular hypertrophy in this population.
Summary:
- Left ventricular mass, assessed via echocardiography in 23 hypertensive patients, correlated significantly with age and systolic blood pressure.
- No significant correlation was found between left ventricular mass and diastolic blood pressure, plasma renin activity, or plasma norepinephrine levels.
- The study suggests that age and systolic blood pressure are the predominant determinants of left ventricular hypertrophy in long-standing arterial hypertension.
Impact:
- Provides insights into the primary drivers of left ventricular hypertrophy in hypertensive patients.
- Highlights the importance of systolic blood pressure control in preventing cardiac remodeling.
- Informs clinical strategies for risk stratification and management of hypertensive heart disease.
Abstract:
In patients with arterial hypertension hemodynamic as well as humoral factors may influence the development of left ventricular hypertrophy. We therefore investigated in 23 patients with long standing hypertension (11 females, 12 males, age 50 +/- 13 years) wether left ventricular mass as determined by echocardiography interrelates with hemodynamic or humoral parameters. Left ventricular mass measured 161 +/- 51 g/m2 and correlated significantly with patients' age (r = 0.55, p less than 0.05) and systolic blood pressure (159 +/- 21 mm Hg, r = 0.51, p less than 0.05) but not with diastolic blood pressure (99 +/- 15 mm Hg, r = 0.23, not significant). Plasma renin activity was 0.6 +/- 0.6 ng/ml/h and plasma norepinephrine levels measured 371 +/- 168 ng/l. Neither of these humoral parameters correlated significantly with left ventricular mass. It is concluded that in long standing hypertension left ventricular hypertrophy is determined predominantly by the elevation of systolic blood pressure and the patients' age.