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Updated: Mar 30, 2026

Osteoclast Derivation from Mouse Bone Marrow
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[Bone turnover marker].

Masakazu Miura, Yuki Satoh

    Nihon Rinsho. Japanese Journal of Clinical Medicine
    |November 5, 2015
    PubMed
    Summary
    This summary is machine-generated.

    Bone turnover markers (BTMs) aid in understanding osteoporosis and guiding treatment selection. Updated guidelines provide reference values and assessment methods for BTMs in clinical practice.

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    Area of Science:

    • Biochemistry
    • Clinical Medicine
    • Endocrinology

    Context:

    • Bone turnover markers (BTMs) are increasingly utilized in clinical practice.
    • Understanding osteoporosis pathogenesis benefits from BTM measurements.
    • BTMs encompass bone formation, resorption, and matrix-related markers.

    Purpose:

    • To summarize recent advancements in the clinical application of BTMs.
    • To highlight updates in the 2012 Japan Osteoporosis Society guidelines regarding BTMs.
    • To emphasize the importance of proper BTM assessment in osteoporosis management.

    Summary:

    • The 2012 Japan Osteoporosis Society guidelines provide updated reference values for BTMs in Japanese individuals and discuss the influence of renal function.
    • Revised flowcharts detail the measurement of bone resorption and formation markers for selecting osteoporosis drug treatments.
    • Guidelines now include evaluations of therapeutic effects for bone antiresorption and formation-promoting drugs using BTMs.

    Impact:

    • BTMs are crucial for selecting appropriate osteoporosis medications.
    • BTMs facilitate the evaluation of drug efficacy in osteoporosis treatment.
    • Proper application and assessment of BTMs can improve patient adherence to osteoporosis therapy.