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Updated: Mar 30, 2026
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Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood
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[Changes in PT and APTT When Administrating Rivaroxaban, a Direct Inhibitor of Activated Factor X]
Rinsho Byori. the Japanese Journal of Clinical Pathology
|November 5, 2015
Summary
Oral rivaroxaban (RX) prolongs prothrombin time (PT) and activated partial thromboplastin time (APTT). Specific reagents correlate PT prolongation with remaining rivaroxaban concentration, aiding monitoring.
Area of Science:
- Pharmacology
- Hematology
Context:
- Rivaroxaban is an oral direct factor Xa inhibitor.
- Monitoring anticoagulant therapy is crucial for patient safety.
Purpose:
- To evaluate the effects of rivaroxaban on PT and APTT.
- To assess the correlation between rivaroxaban concentration and coagulation times.
- To determine reagent sensitivity for monitoring rivaroxaban.
Summary:
- Oral rivaroxaban administration prolonged PT and APTT in healthy subjects, with maximal effects observed at 4 hours.
- Different reagents showed varying sensitivities, with those sensitive to factors X and VII exhibiting greater prolongation.
- PT and APTT correlated positively with rivaroxaban concentration, and levels remained elevated 24 hours post-dose.
Impact:
- Results suggest PT can estimate remaining rivaroxaban concentration using sensitive reagents.
- This finding may inform clinical practice for monitoring rivaroxaban therapy.
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