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Related Experiment Video

Updated: Mar 30, 2026

Synthesis of Core-shell Lanthanide-doped Upconversion Nanocrystals for Cellular Applications
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Controlling upconversion nanocrystals for emerging applications.

Bo Zhou1, Bingyang Shi2, Dayong Jin2,3

  • 1Institute of Materials Research and Engineering, A*STAR (Agency for Science, Technology and Research), 3 Research Link, 117602 Singapore, Singapore.

Nature Nanotechnology
|November 5, 2015
PubMed
Summary
This summary is machine-generated.

Lanthanide-doped upconversion nanocrystals offer efficient anti-Stokes emission for diverse applications. This review covers their fundamental concepts, challenges in tuning color and enhancing luminescence, and functionalization strategies for imaging and therapy.

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Optics

Background:

  • Lanthanide-doped upconversion nanocrystals (UCNs) exhibit anti-Stokes emission at lower pump intensities than traditional nonlinear optical methods.
  • Key properties include large anti-Stokes shifts, narrow emission spectra, and long excited-state lifetimes, enabling various applications.

Purpose of the Study:

  • To review the fundamental concepts of UCNs.
  • To examine technical challenges in emission color tuning and luminescence enhancement.
  • To highlight functionalization strategies for UCNs.

Main Methods:

  • Review of existing literature on UCNs.
  • Analysis of fundamental principles governing upconversion processes.
  • Examination of strategies for modifying UCN properties.

Main Results:

  • UCNs provide a viable alternative to conventional nonlinear optics for anti-Stokes emission.
  • Significant progress has been made in controlling UCN emission color and intensity.
  • Advanced functionalization techniques expand UCN utility.

Conclusions:

  • UCNs possess unique properties suitable for advanced applications.
  • Addressing challenges in color tuning and luminescence is crucial for further development.
  • Functionalized UCNs show great promise for multimodal imaging, cancer therapy, displays, and photonics.