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PTEN and TP53 Mutations in Oncocytic Follicular Carcinoma

Shuanzeng Wei1, Virginia A LiVolsi2, Kathleen T Montone3

  • 1Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA. weishuanzeng@hotmail.com.

Endocrine Pathology
|November 5, 2015
PubMed

Insights

Aggressive Oncocytic Follicular Carcinoma (OFC) showed frequent TP53 mutations (42%) and PTEN mutations (25%). These genetic alterations may play a role in the development of this rare thyroid cancer.

Area of Science:

  • Oncology
  • Genetics
  • Endocrinology

Background:

  • Oncocytic follicular carcinoma (OFC), also known as Hürthle cell carcinoma, accounts for 3-4% of thyroid cancers.
  • OFC can exhibit more aggressive behavior and poorer survival rates than non-oncocytic thyroid carcinomas.

Purpose of the Study:

  • To investigate the molecular alterations in clinically aggressive Oncocytic Follicular Carcinoma (OFC).
  • To identify potential genetic drivers in a heterogeneous cohort of aggressive OFC cases.

Main Methods:

  • Targeted next-generation sequencing (NGS) was performed on 12 OFC cases.
  • Gene panels of 47 or 20 genes, commonly mutated in solid tumors, were utilized.

Main Results:

  • TP53 mutations were identified in 5 out of 12 cases (42%).
  • PTEN mutations were observed in 3 cases, all of which also had TP53 mutations (25%).
  • The cohort included angioinvasive OFC, poorly differentiated OFC, and OFC with anaplastic or capsular changes.

Conclusions:

  • TP53 and PTEN mutations are potentially involved in the pathogenesis of Oncocytic Follicular Carcinoma.
  • Further research with larger cohorts is necessary to confirm these findings and understand their clinical implications.
Keywords:
Hürthle cell carcinomaMutationNext generation sequencingOncocytic follicular carcinomaPTENTP53Thyroid

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