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Recent Advances in the Treatment of Immune-Mediated Inflammatory Diseases

Sander W Tas1,2, Dominique L P Baeten3,4

  • 1Department of Clinical Immunology & Rheumatology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 22600, 1105, Amsterdam, The Netherlands.

Methods in Molecular Biology (Clifton, N.J.)
|November 5, 2015
PubMed

The treatment of immune-mediated inflammatory diseases (IMIDs) has dramatically improved over the last two decades by the development of a series of targeted biological therapies. This paper focuses on new developments in the treatment of IMIDs. In particular, we discuss how different ways of targeting the same mediators can lead to different efficacy and safety profiles, using B cell targeting as example. In addition, we discuss the emerging field of 'small molecules' that target specifically intracellular processes related to cytokine signaling, cell activation, cell migration, and other processes relevant to tissue inflammation.

Keywords:
B cellsImmune-mediated inflammatory diseasesSignal transductionTreatment

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