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Context and the human microbiome.

Daniel McDonald1,2, Amanda Birmingham3, Rob Knight4,5

  • 1Department of Computer Science, University of Colorado at Boulder, Boulder, CO, 80304, USA. mcdonadt@colorado.edu.

Microbiome
|November 5, 2015
PubMed
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Human microbiome reference datasets are crucial for research, offering context and aiding study design. The American Gut Project is developing a comprehensive resource by engaging the public globally.

Area of Science:

  • Microbiome research
  • Human health and disease
  • Epidemiology

Background:

  • Reference datasets are vital for human microbiome research, providing epidemiological context for meta-analyses.
  • Large datasets aid in hypothesis development, testing, and practical study design, including sample size determination.
  • Existing resources have limitations and present technical challenges for researchers.

Purpose of the Study:

  • To discuss the importance and usage of human microbiome reference sets.
  • To highlight the limitations of current resources and associated technical challenges.
  • To present the American Gut Project's contributions to creating a comprehensive reference set.

Main Methods:

  • The American Gut Project engages the general public to gather data on health, disease, lifestyle, and diet.

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  • International collaborations are utilized to expand the scope and reach of the project.
  • The project aims to address limitations in existing reference resources.
  • Main Results:

    • The American Gut Project is contributing to the development of a comprehensive human microbiome reference set.
    • Public engagement facilitates the characterization of health, disease, lifestyle, and dietary factors.
    • Global collaborations are extending the project's efforts internationally.

    Conclusions:

    • Comprehensive human microbiome reference sets are essential for advancing research.
    • The American Gut Project is a significant effort to improve existing resources through public participation and global collaboration.
    • This initiative has the potential to enhance our understanding of the human microbiome in diverse populations.