Related Experiment Video
Updated: Mar 30, 2026
Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models
Published on: December 3, 2019
Left ventricular mass in HIV-infected patients
J Olalla1, M Pombo2, A Del Arco1
1Área de Medicina Interna, Agencia Sanitaria Costa del Sol, Consejería de Salud, Junta de Andalucía, Marbella, Málaga, España.
Insights
HIV patients with higher vascular risk (VR10) and a history of nevirapine use showed increased left ventricular mass (LVM). This finding highlights potential cardiovascular concerns in HIV management.
Area of Science:
- Cardiology
- Infectious Diseases
- Public Health
Background:
- HIV infection is linked to increased vascular events and higher left ventricular mass (LVM).
- Elevated LVM is an independent predictor of mortality.
- Previous studies indicate HIV-infected individuals have greater LVM than uninfected populations.
Purpose of the Study:
- To determine the distribution of LVM in a large cohort of HIV-infected patients.
- To identify factors associated with increased LVM in this population.
Main Methods:
- A cross-sectional study involving 400 HIV-infected patients.
- Transthoracic echocardiography (TTE) was used to measure LVM.
- Data collected included demographics, viroimmunological status, cardiovascular risk factors, and antiretroviral drug history.
Main Results:
- Mean LVM was 39.54g/m(2.7) in 388 patients.
- Factors associated with increased LVM included age, height, BMI, vascular risk at 10 years (VR10), hypertension, dyslipidemia, cardiovascular medications, and nevirapine use.
- Multivariate analysis identified VR10 and nevirapine use as significant factors.
Conclusions:
- Vascular risk at 10 years (VR10) may be associated with increased left ventricular mass.
- The association with nevirapine might be due to indication bias.
Background:
The HIV infection has been associated with an increased incidence of vascular events. Left ventricular mass (LVM) is independently associated with greater overall mortality. Various studies have shown that patients with HIV infection have higher LVM than the uninfected population. We aim to describe the distribution of LVM in an extensive series of patients with HIV infection, and the factors associated with its increase.
Patients And Methods:
A cross-sectional study was performed in HIV-infected patients followed in our center from 1 December 2009 to 28 February 2011. A transthoracic echocardiography (TTE) was performed in all patients who gave their consent. Demographic variables, viroimmunological status, cardiovascular risk factors, vascular risk at 10 years (VR10) and history of exposure to antiretroviral drugs were collected. LVM was considered to be the quantitative dependent variable. A univariate analysis was performed, including in the multivariate analysis those variables with P<,05.
Results:
A TTE was performed in 400 patients, and the LVM was calculated in 388. Mean age was 45 years, 75.5 males. Mean LVM was 39.54g/m(2.7)(95% CI: 38.35-40.73). Age, height, body mass index, VR10, hypertension, dyslipidemia, different medications within the cardiovascular area and having taken nevirapine have been used in the history of the patient were associated to greater LVM. In the multivariate analysis, use of nevirapine in the history of the patient and VR10 remained in the model.
Conclusions:
VR10 may be associated with greater LVM. The relationship with nevirapine may respond to an indication bias.
More Related Videos
07:21Processing of Bronchoalveolar Lavage Fluid and Matched Blood for Alveolar Macrophage and CD4+ T-cell Immunophenotyping and HIV Reservoir Assessment
Published on: June 23, 2019
11:14Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture
Published on: October 12, 2018
