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Updated: Mar 30, 2026

Preoxygenation Techniques for Tracheal Intubation in Critically Ill Adults Utilizing Oxygen Mask and Noninvasive Ventilation
Published on: December 5, 2025
Predictors of outcome for patients with severe respiratory failure requiring non invasive mechanical ventilation
1Department of Respiratory Diseases, IRCCS San Raffaele - Pisana, Rome Italy. vittoria.conti@gmail.com.
Objective:
Failure to identify patients in whom non-invasive ventilation (NIV) would be unsuccessful may cause inappropriate delay in intubation. Aim of this study was to determine predictors of NIV failure.
Patients And Methods:
We retrospectively evaluated COPD patients, undergoing NIV for at least 12h because of hypercapnic acute respiratory failure. Univariable and multivariable analyses were performed on: age, gender, APACHE II and GCS, gas exchange at admission, during NIV and at discharge/death, length of stay. ROC analysis for pH START and APACHE II were performed.
Results:
Among 201 individuals enrolled, NIV failed in 50. In the logistic regression model only APACHE II was found to have an independent effect on the outcome (p < 0.0001, OR 1.179, 95% CI 1.101-1.263 as quantitative variable; p < 0.0001, OR 3.753, 95% CI 1.798-7.835, as qualitative variable, > 20.5).
Conclusions:
APACHE II may be a crucial parameter in predicting NIV failure; further multicentric studies are needed to better define NIV indications.
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