Assessment of the left ventricular systolic function in multi-vessel coronary artery disease with normal wall motion by two-dimensional speckle tracking echocardiography
Related Experiment Video
Updated: Mar 30, 2026
Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation
Published on: October 20, 2016
1Department of Ultrasound Imaging, Xiangyang Hospital Affiliated to Hubei University of Medicine, Xiangyang, Hubei, China. jiabaoyin-xf1227@163.com.
Insights
Two-dimensional speckle tracking echocardiography reveals impaired left ventricular systolic function in multi-vessel coronary artery disease patients, even with normal wall motion. This technique helps detect subtle systolic dysfunction in coronary artery disease.
Area of Science:
- Cardiology
- Echocardiography
- Medical Imaging
Background:
- Multi-vessel coronary artery disease (MVD) can affect left ventricular (LV) systolic function.
- Assessing LV systolic function in MVD patients with normal wall motion (NWM-MVD) is crucial for early detection and management.
- Two-dimensional speckle tracking echocardiography (2D-STE) offers advanced quantitative analysis of myocardial deformation.
Purpose of the Study:
- To evaluate the clinical utility of 2D-STE in analyzing LV systolic function.
- To identify subtle impairments in LV systolic function in NWM-MVD patients.
Main Methods:
- Forty-five NWM-MVD patients and 36 controls underwent echocardiography.
- LV images were analyzed using Q-analysis software for peak systolic strain.
- Global longitudinal strain (GLS), global circumferential strain (GCS), and global radial strain (GRS) were calculated for LV segments.
Main Results:
- Conventional echocardiographic indices were similar between NWM-MVD and control groups.
- NWM-MVD patients exhibited significantly lower GLS, Bas-GLS, Mid-GLS, Bas-GCS, Mid-GCS, GRS, and Bas-GRS compared to controls.
- Coronary occlusion was evident in 85.71% of NWM-MVD patients.
Conclusions:
- 2D-STE can detect impaired LV longitudinal, circumferential, and radial systolic functions in NWM-MVD patients.
- These subtle functional impairments may not be apparent with conventional echocardiography.
- 2D-STE provides valuable insights into the subclinical effects of MVD on LV mechanics.
Objective:
To evaluate the clinical value of two-dimensional speckle tracking echocardiography for analyzing the left ventricular systolic function in patients with multi-vessel coronary artery disease with normal wall motion (NWM-MVD).
Patients And Methods:
Forty-five NWM-MVD patients and thirty-six subjects with low risk of coronary artery disease (control group) were enrolled in this study. Echocardiogram images of the short axis of the left ventricle and apical long axis were obtained. The Q-analysis software was used to analyze the peak systolic strain of the left ventricular segments and the global longitudinal strain (GLS). We calculated the left ventricular global circumferential strain (GCS) and the radial strain (GRS), as well as the longitudinal, radial and circumferential strain of the basal (Bas-GLS, Bas-GCS, Bas-GRS), middle (Mid-GLS, Mid-GCS, Mid-GRS) and apical segments (Ap-GLS, Ap-GCS, Ap-GRS).
Results:
(1) The coronary occlusion or subtotal occlusion were visible in 85.71% of the NWM-MVD patients. (2) The heart rate of the NWM-MVD patients was lower than that of the control group [(61.78 ± 6.76) beats/min vs. (66.13 ± 6.24) beats/min, p < 0.05]. The conventional ultrasonic measurement indices are similar between the NWM-MVD group and the control group (p > 0.05). (3) Compared with the control group, the GLS, Bas-GLS, Mid-GLS, Bas-GCS, Mid-GCS, GRS and Bas-GRS were lower in the NWM-MVD group (p < 0.05).
Conclusions:
The longitudinal, circumferential and radial systolic functions of the NWM-MVD patients were impaired at different degrees.
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