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Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome
Published on: June 15, 2016
Aberrant decrease of microRNA19b regulates TSLP expression and contributes to Th17 cells development in myasthenia
Zhongkui Wang1, Yuping Chen2, Shengjie Xu2
1Department of Neurology, Chinese PLA General Hospital, Beijing 100853, China; Department of Neurology, The 309th Hospital of Chinese PLA, Beijing 100091, China.
Abstract:
Myasthenia gravis (MG) is an organ-specific autoimmune disease. The imbalance of T helper type 17 cells (Th17) plays a key role in the pathogenesis of thymomatous MG. But the regulatory mechanism for Th17 cell development in MG-related thymoma remains undefined. Here we demonstrated that thymic stromal lymphopoietin (TSLP) is significantly decreased in thymomas. We also proved that TSLP was post-trancriptionally regulated by microRNA-19b. The expression of microRNA-19b was negatively correlated with the expression of TSLP mRNA and protein in thymomas. This study indicated that the elevation of microRNA-19b suppressed TSLP expression and then influenced T cell development in thymomatous MG.
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