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Updated: Mar 30, 2026
Restraint to Induce Stress in Mice and Rats
Published on: December 6, 2024
Systemic Staphylococcus aureus infection in restraint stressed mice modulates impaired immune response resulting in
Sayantika Mahanti1, Arnab Majhi1, Kiran Kundu2
1Department of Physiology, Immunology Laboratory, University of Calcutta, University Colleges of Science and Technology, 92 APC Road, Calcutta 700009, West Bengal, India.
Abstract:
Stress leads to immune malfunction and increased susceptibility to infection resulting in impaired cognitive behavior and depression. Working with an animal model of Staphylococcus aureus infection and restraint stress we demonstrated impaired immune response and altered behavior against the S. aureus infection after exposure to acute or chronic restraint stress. This enhanced the resistance of mice to S. aureus infection via inhibiting the production of pro-inflammatory cytokines, free radicals, and upregulating corticosterone and anti-inflammatory cytokine production, resulting in altered exploratory behavior, compared to non-stressed infected group (P<0.05), thereby helping the animals to recover from depressive-like symptoms due to stress.
