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Role of Nitric Oxide in Glioblastoma Therapy: Another Step to Resolve the Terrible Puzzle ?

R Altieri1, M Fontanella2, A Agnoletti1

  • 1Department of Neurosurgery, University of Turin, Italy.

Translational Medicine @ Unisa
|November 5, 2015
PubMed

Insights

Glioblastoma Multiforme (GBM) is an aggressive brain tumor. Understanding the role of nitric oxide (NO) in GBM may improve treatment by addressing tumor recurrence and resistance to therapies.

Area of Science:

  • Neuro-oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Glioblastoma Multiforme (GBM) is the most common and aggressive primary brain tumor.
  • Current treatments for GBM often fail due to tumor recurrence and resistance to chemotherapy and radiotherapy.
  • Nitric oxide (NO) is a molecule implicated in the pathophysiology of gliomas.

Purpose of the Study:

  • To elucidate the role of nitric oxide (NO) in Glioblastoma Multiforme (GBM).
  • To explore how NO influences key cellular processes relevant to GBM treatment resistance and recurrence.

Main Methods:

  • Literature review on nitric oxide's function in glioma.
  • Analysis of existing research on NO's involvement in apoptosis, radiosensitization, and chemosensitization.
  • Synthesis of findings to understand NO's potential impact on GBM.

Main Results:

  • Nitric oxide (NO) has been shown to be involved in the induction of apoptosis in cancer cells.
  • NO plays a role in enhancing the sensitivity of tumors to both radiation (radiosensitization) and chemotherapy (chemosensitization).

Conclusions:

  • Clarifying the precise role of nitric oxide (NO) in Glioblastoma Multiforme (GBM) is crucial.
  • A deeper understanding of NO's mechanisms may lead to improved therapeutic strategies for GBM, potentially overcoming treatment resistance and reducing recurrence.
Keywords:
ChemotherapyGlioblastomaGliomaNO synthasesNitric OxideRadiotheraypy

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