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Stereotactic Radiosurgery for Gynecologic Cancer

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Published on: April 17, 2012

Preoperative Radiosurgery for Soft Tissue Sarcoma.

Gregory J Kubicek¹, Tamara LaCouture¹, Maureen Kaden²

¹Departments of Radiation Oncology.

American Journal of Clinical Oncology

|November 5, 2015

Summary

This summary is machine-generated.

Stereotactic body radiotherapy (SBRT) offers a shorter preoperative treatment for soft tissue sarcomas (STSs), proving well-tolerated and convenient. Initial results show satisfactory surgical outcomes and encourage further investigation into this advanced radiosurgery technique.

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Area of Science:

Oncology
Radiation Oncology
Surgical Oncology

Background:

Soft tissue sarcomas (STSs) conventionally treated with 5 weeks of preoperative radiation (approx. 50 Gy) followed by surgery.
Stereotactic body radiotherapy (SBRT) presents a novel, accelerated approach to preoperative radiation for STSs.

Purpose of the Study:

To evaluate the initial experience and feasibility of a phase II single-arm study using preoperative SBRT followed by surgical resection for STSs.
To assess the safety, tolerability, and efficacy of a 5-fraction SBRT regimen in patients with STSs.

Main Methods:

Thirteen patients with 14 STSs received preoperative SBRT (35-40 Gy in 5 fractions) followed by surgical resection.
Tumor locations included leg (10), arm (2), and groin (2), with median tumor size of 7.6 cm.
Treatment planning involved specific isodose lines and dose constraints to organs at risk, with a median follow-up of 279 days.

Main Results:

All patients achieved negative surgical margins.
Acute toxicity included 4 cases of skin reactions (2 grade 2, 2 grade 3), which resolved by surgery.
Median tumor necrosis was 60%, with 1 local recurrence and 7 distant recurrences observed.

Conclusions:

Preoperative SBRT for STSs is well-tolerated, convenient, and offers a significantly shorter treatment course.
This approach facilitates quicker progression to surgery and subsequent chemotherapy.
Initial surgical complication rates and tumor control rates are satisfactory, warranting further investigation.