Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Birth Control Methods01:22

Birth Control Methods

7.3K
Vasectomy is a surgical form of male sterilization that involves severing and sealing the vasa deferentia, preventing sperm from mixing with semen during ejaculation. Because a vasectomy does not impact the testes' ability to produce testosterone, hormone levels, libido, and sexual function generally remain unchanged. While vasectomy is highly effective in preventing pregnancy, with a success rate near 99.85%, rare cases of recanalization (spontaneous reconnection) can occur. Although...
7.3K
Intrauterine Drug Delivery Systems01:21

Intrauterine Drug Delivery Systems

127
Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...
127
Oral Drug Delivery Systems: Continuous-Release Systems01:26

Oral Drug Delivery Systems: Continuous-Release Systems

212
Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...
212
Modified-Release Drug Delivery Systems: Drug Release Characteristics01:22

Modified-Release Drug Delivery Systems: Drug Release Characteristics

178
Drug release from modified-release dosage forms is designed to achieve specific therapeutic effects by controlling the rate and extent of drug release. The classification of these drug release systems is based on key pharmacokinetic assumptions: drug disposition follows first-order kinetics, drug release is the rate-limiting step in absorption, and the released drug is rapidly and completely absorbed.There are four major models of drug release patterns. The first model is the slow zero-order...
178
Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

89
Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
89
Drug Delivery Systems: Different Types01:27

Drug Delivery Systems: Different Types

240
Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
240

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Scientific abstracts, featured research at the 2025 Society of Family Planning Annual Meeting.

Contraception·2025
Same author

One-in-ten adolescents and young adults report changes in their sexual orientation identity over 2-month follow-up: Results from a longitudinal cohort study.

Psychology of sexual orientation and gender diversity·2025
Same author

Benchmarking the Current Landscape: Insights From an Association of American Cancer Institutes Survey on Academic Cancer Service Lines.

JCO oncology practice·2025
Same author

Featured research at the 2024 Society of Family Planning Annual Meeting.

Contraception·2024
Same author

North American Cancer Center Clinical Research Capacity and Benchmarking in the Postpandemic Era.

JCO oncology practice·2024
Same author

The experiences of parents with a child born after preimplantation genetic testing.

Fertility and sterility·2024
Same journal

Management of hypertensive disorders in pregnancy.

Current opinion in obstetrics & gynecology·2026
Same journal

Updates in group prenatal care research.

Current opinion in obstetrics & gynecology·2026
Same journal

Complex benign gynecology in perimenopause: current evidence and future directions.

Current opinion in obstetrics & gynecology·2026
Same journal

Role of insulin in female reproduction.

Current opinion in obstetrics & gynecology·2026
Same journal

Urinary tract involvement in endometriosis: current evidence and clinical insights into navigating diagnosis and management.

Current opinion in obstetrics & gynecology·2026
Same journal

Updates in ultrasound imaging of adenomyosis and clinical impacts.

Current opinion in obstetrics & gynecology·2026
See all related articles

Related Experiment Video

Updated: Mar 30, 2026

High Throughput In Vitro Assessment of Latency Reversing Agents on HIV Transcription and Splicing
07:18

High Throughput In Vitro Assessment of Latency Reversing Agents on HIV Transcription and Splicing

Published on: January 22, 2019

6.3K

Update on long-acting reversible methods.

Jennifer Conti1, Kate Shaw

  • 1Division of Family Planning, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California, USA.

Current Opinion in Obstetrics & Gynecology
|November 5, 2015
PubMed
Summary
This summary is machine-generated.

Long-acting reversible contraceptives (LARCs) are recommended as first-line contraception. Recent data show LARCs are safe and effective for diverse populations, including postpartum and postabortion individuals, and can reduce unintended pregnancies.

More Related Videos

Methods Development for Blood Borne Macrophage Carriage of Nanoformulated Antiretroviral Drugs
18:46

Methods Development for Blood Borne Macrophage Carriage of Nanoformulated Antiretroviral Drugs

Published on: December 9, 2010

13.8K
Methods for Studying Uterine Contributions to Pregnancy Establishment in an Ovariectomized Mouse Model
06:49

Methods for Studying Uterine Contributions to Pregnancy Establishment in an Ovariectomized Mouse Model

Published on: April 7, 2023

2.4K

Related Experiment Videos

Last Updated: Mar 30, 2026

High Throughput In Vitro Assessment of Latency Reversing Agents on HIV Transcription and Splicing
07:18

High Throughput In Vitro Assessment of Latency Reversing Agents on HIV Transcription and Splicing

Published on: January 22, 2019

6.3K
Methods Development for Blood Borne Macrophage Carriage of Nanoformulated Antiretroviral Drugs
18:46

Methods Development for Blood Borne Macrophage Carriage of Nanoformulated Antiretroviral Drugs

Published on: December 9, 2010

13.8K
Methods for Studying Uterine Contributions to Pregnancy Establishment in an Ovariectomized Mouse Model
06:49

Methods for Studying Uterine Contributions to Pregnancy Establishment in an Ovariectomized Mouse Model

Published on: April 7, 2023

2.4K

Area of Science:

  • Reproductive Health
  • Contraception
  • Women's Health

Background:

  • Long-acting reversible contraceptives (LARCs) have seen significant clinical and academic advancements.
  • Professional medical organizations now recommend LARCs as a primary contraceptive choice for all women.

Purpose of the Study:

  • To review recent data on the use and effectiveness of LARCs.
  • To highlight the suitability of LARCs in special circumstances and for extended use.

Main Methods:

  • Review of recent clinical data and evidence.
  • Analysis of LARC use in diverse populations and special circumstances.
  • Evaluation of safety and efficacy of intrauterine devices (IUDs) for extended use.

Main Results:

  • LARC methods are supported for use in adolescents, nulliparous women, and immediately postpartum and postabortion.
  • Traditional pain control and cervical preparation for IUD insertion may not be necessary.
  • Extended use of IUDs is demonstrably safer and more effective than previously understood.

Conclusions:

  • Rising LARC uptake in the US has the potential to significantly reduce unintended pregnancies and abortion rates.
  • LARCs are an effective contraceptive option for the majority of women.