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Robot-Assisted Kidney Transplantation
Published on: July 19, 2021
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Bortezomib in kidney transplantation
Neil Shah1, Joseph Meouchy, Yasir Qazi
1aKeck School of Medicine bDepartment of Nephrology cKidney-Pancreas Transplant Program, University of Southern California, Los Angeles, California, USA.
Current Opinion in Organ Transplantation
|November 5, 2015
Summary
Bortezomib shows promise in preventing kidney transplant rejection by lowering antibody levels and improving early graft survival. Further research is needed to confirm its long-term effectiveness and optimal timing for administration.
Area of Science:
- Nephrology
- Immunology
- Transplantation Medicine
Background:
- Kidney transplant rejection remains a significant challenge in organ transplantation.
- Developing effective strategies for prevention and treatment is crucial for improving graft survival.
- Bortezomib, a proteasome inhibitor, has emerged as a potential therapeutic agent.
Purpose of the Study:
- To evaluate the efficacy of bortezomib in preventing and treating kidney transplant rejection.
- To synthesize recent findings on bortezomib's role in kidney transplantation.
Main Methods:
- Systematic review of recent literature (last 2 years).
- Analysis of studies comparing bortezomib with traditional immunosuppressants.
- Evaluation of bortezomib's impact on donor-specific antibody levels and graft survival.
Main Results:
- Pre-transplant or early post-transplant bortezomib administration lowered donor-specific antibody levels and improved graft survival.
- Evidence for bortezomib's effectiveness in treating established antibody-mediated rejection is limited.
- High short-term success rates were observed with bortezomib as an early desensitizing agent.
Conclusions:
- Bortezomib demonstrates potential as an early desensitizing agent in kidney transplantation.
- Further randomized controlled trials are necessary to establish long-term efficacy and optimal administration protocols.
- More research is needed to clarify bortezomib's role in treating antibody-mediated rejection post-transplant.
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