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Updated: Mar 30, 2026

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Nab-paclitaxel in patients with metastatic melanoma

Roberto A Leon-Ferre1, Svetomir N Markovic1

  • 1a Department of Oncology , Mayo Clinic , Rochester , MN , USA.

Expert Review of Anticancer Therapy
|November 5, 2015
PubMed

Insights

Nab-paclitaxel shows activity in advanced melanoma, offering a salvage treatment option for patients resistant to newer therapies. This chemotherapy agent plays a role when immune and targeted treatments are no longer effective.

Area of Science:

  • Oncology
  • Dermatology
  • Pharmacology

Background:

  • Cutaneous melanoma is a highly aggressive human malignancy.
  • Metastatic melanoma treatment saw limited progress for two decades.
  • Recent advances include immune and targeted therapies, revolutionizing management.

Purpose of the Study:

  • To summarize the role of nab-paclitaxel in advanced melanoma management.
  • To highlight nab-paclitaxel as a salvage therapy option.

Main Methods:

  • Review of clinical trial data on nab-paclitaxel in metastatic melanoma.
  • Analysis of nab-paclitaxel's efficacy in patients refractory to other treatments.

Main Results:

  • Nab-paclitaxel demonstrates activity in metastatic melanoma.
  • It serves as a viable salvage treatment option.

Conclusions:

  • Chemotherapy, including nab-paclitaxel, retains a role in metastatic melanoma treatment.
  • Nab-paclitaxel is valuable for patients who have exhausted immune-based or targeted therapies.
Keywords:
Melanomaalbumin-bound paclitaxelcremophore-free paclitaxelnab-paclitaxelsolvent-free paclitaxeltaxanes

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