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Related Concept Videos

Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

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The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
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Connective Tissue Cell Types01:22

Connective Tissue Cell Types

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Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
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Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

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The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
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Vitamins01:30

Vitamins

3.0K
Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
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Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

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The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
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Dosage Regimen: Fixed Dose01:01

Dosage Regimen: Fixed Dose

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Fixed-dose regimens are a common approach to administer drugs to achieve and maintain desired levels of the drug in the body. In this dosing strategy, a specific amount of medication is given at regular intervals, often multiple times a day, to ensure a consistent drug concentration in the bloodstream.
Fixed-dose regimens can be used for various routes of administration, including intravenous (IV) injections and oral medications. For IV administration, a predetermined amount of the drug is...
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Related Experiment Video

Updated: Mar 30, 2026

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
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[Vitamin D supplementation for everybody everytime?].

Jan Kramer1

  • 1Medizinische Klinik I, Universität zu Lübeck.

Deutsche Medizinische Wochenschrift (1946)
|November 5, 2015
PubMed
Summary

Vitamin D, primarily from sunlight, is crucial for calcium and bone health. Widespread deficiency raises questions about the necessity of vitamin D supplementation for the general population.

Area of Science:

  • Endocrinology
  • Nutritional Science
  • Dermatology

Context:

  • Vitamin D is mainly synthesized in the skin via UVB exposure, as few foods are rich in it.
  • Vitamin D undergoes hydroxylation to become 25-hydroxy-vitamin D and then the active hormone 1,25-dihydroxy-vitamin D.
  • The active form of vitamin D is vital for calcium and bone metabolism.

Purpose:

  • To explore the significance of vitamin D in human health.
  • To highlight the prevalence and consequences of vitamin D deficiency.
  • To address the debate surrounding vitamin D supplementation.

Summary:

  • Vitamin D deficiency can lead to bone demineralization and is linked to osteoporosis and falls in the elderly.
  • The vitamin D receptor is present in all nucleated cells, indicating broad regulatory functions.

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  • Subclinical vitamin D deficiency is common, prompting food fortification and discussions on supplementation.

    • Impact:

    • Understanding vitamin D's role is critical for public health strategies.
    • Identifies a widespread nutritional issue with significant health implications.
    • Informs public health policies regarding food fortification and supplementation recommendations.