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Enoxacin absorption and elimination characteristics.

R D Toothaker1

  • 1Parke Davis Pharmaceutical Research Division, Warner-Lambert Company, Ann Arbor, Michigan.

Clinical Pharmacokinetics
|January 1, 1989
PubMed
Summary

Enoxacin, a fluoroquinolone antibiotic, shows excellent oral absorption and bioavailability, allowing for convenient twice-daily dosing. Avoid concurrent use with antacids to ensure optimal absorption and efficacy.

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Area of Science:

  • Pharmacology
  • Microbiology
  • Drug Interactions

Background:

  • Enoxacin is a novel fluoroquinolone antibiotic.
  • Understanding its pharmacokinetic profile is crucial for effective clinical use.

Purpose of the Study:

  • To evaluate the oral bioavailability, pharmacokinetics, and drug interactions of enoxacin.
  • To determine the impact of food, renal function, and antacids on enoxacin's absorption and elimination.

Main Methods:

  • Pharmacokinetic studies involving oral and intravenous administration of enoxacin.
  • Assessment of enoxacin absorption with and without food.
  • Evaluation of enoxacin's interaction with theophylline and magnesium-aluminium hydroxide antacid.

Main Results:

  • Enoxacin exhibits rapid, extensive oral absorption with dose-independent bioavailability, minimally affected by food.
  • The elimination half-life (t1/2) of 4-6 hours supports twice-daily dosing without accumulation.
  • Enoxacin decreases theophylline clearance and significantly reduced oral bioavailability when coadministered with antacids.

Conclusions:

  • Enoxacin is a highly effective oral antibiotic with favorable bioavailability and elimination characteristics.
  • Dosage adjustments are simple in renal dysfunction, and elderly patients generally do not require changes.
  • Concurrent administration with antacids should be avoided to maintain therapeutic efficacy.

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