Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Prochirality02:05

Prochirality

5.4K
The concept of prochirality leads to the nomenclature of the individual faces of a molecule and plays a crucial role in the enantioselective reaction. It is a concept where two or more achiral molecules react to produce chiral products. A typical process is the reaction of an achiral ketone to generate a chiral alcohol. Here, the achiral reactant reacts with an achiral reducing agent, sodium borohydride, to generate an equimolar mixture of the chiral enantiomers of the product. For example, an...
5.4K
Chirality at Nitrogen, Phosphorus, and Sulfur02:30

Chirality at Nitrogen, Phosphorus, and Sulfur

7.4K
Chirality is most prevalent in carbon-based tetrahedral compounds, but this important facet of molecular symmetry extends to sp3-hybridized nitrogen, phosphorus and sulfur centers, including trivalent molecules with lone pairs. Here, the lone pair behaves as a functional group in addition to the other three substituents to form an analogous tetrahedral center that can be chiral.
A consequence of chirality is the need for enantiomeric resolution. While this is theoretically possible for all...
7.4K
Chirality in Nature02:30

Chirality in Nature

18.0K
Chirality is the most intriguing yet essential facet of nature, governing life’s biochemical processes and precision. It can be observed from a snail shell pattern in a macroscopic world to an amino acid, the minutest building block of life. Most of the snails around the world have right-coiled shells because of the intrinsic chirality in their genes. All the amino acids present in the human body exist in an enantiomerically pure state, except for glycine - the sole achiral amino acid.
18.0K
Stereoisomerism of Cyclic Compounds02:33

Stereoisomerism of Cyclic Compounds

11.9K
In this lesson, we delve into the role of ring conformation and its stability, which determines the spatial arrangement and, consequently, the molecular symmetry and stereoisomerism of cyclic compounds. 1,2-Dimethylcyclohexane is used as a case study to evaluate the possible number of stereoisomers. Here, given the multiple (n = 2) chiral centers, there are 2n = 4 possible configurations that lack a plane of symmetry, as the ring skeleton exists in a non-planar chair conformation. In addition,...
11.9K
Chirality02:25

Chirality

32.3K
Chirality is a term that describes the lack of mirror symmetry in an object. In other words, chiral objects cannot be superposed on their mirror images. For example, our feet are chiral, as the mirror image of the left foot, the right foot, cannot be superposed on the left foot.
Chiral objects exhibit a sense of handedness when they interact with another chiral object. For example, our left foot can only fit in the left shoe and not in the right shoe. Achiral objects — objects that have...
32.3K
Molecules with Multiple Chiral Centers02:25

Molecules with Multiple Chiral Centers

16.4K
Molecules that possess multiple chiral centers can afford a large number of stereoisomers. For instance, while some molecules like 2-butanol have one chiral center, defined as a tetrahedral carbon atom with four different substituents attached, several molecules like butane-2,3-diol have multiple chiral centers. A simple formula to predict the number of stereoisomers possible for a molecule with n chiral centers is 2n. However, there can be a lower number where some of the stereoisomers are...
16.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Controlled Dimerization of Rhodium(I) Isocyanides Enables Photophysical Properties Beyond Mononuclear Complexes.

JACS Au·2026
Same author

UV photo-uncaging of Ru(II)-polypyridyl bioconjugates in high vacuum.

Physical chemistry chemical physics : PCCP·2026
Same author

How Much Chirality is Enough?

Chimia·2026
Same author

Non-Dilute Synthesis of Macrodiolides and Macrotetrolides Enabled by Confinement Catalysis.

Angewandte Chemie (International ed. in English)·2026
Same author

Bending the Macrocycle: A Deep Dive into Curved Porphyrinoids.

Chimia·2026
Same author

Photoactive four-coordinate copper(I) complexes based on chelating diimine, diphosphine, and diisocyanide ligands with high excited-state energies.

Dalton transactions (Cambridge, England : 2003)·2026

Related Experiment Video

Updated: Mar 30, 2026

Self-assembling Morphologies Obtained from Helical Polycarbodiimide Copolymers and Their Triazole Derivatives
09:22

Self-assembling Morphologies Obtained from Helical Polycarbodiimide Copolymers and Their Triazole Derivatives

Published on: February 7, 2017

8.3K

Tuning Helical Chirality in Polycyclic Ladder Systems.

Michel Rickhaus1, Oliver T Unke1, Rajesh Mannancherry1

  • 1Department of Chemistry, University of Basel, St. Johanns-Ring 19, 4056 Basel (Switzerland).

Chemistry (Weinheim an Der Bergstrasse, Germany)
|November 6, 2015
PubMed
Summary

Researchers developed novel helical model compounds, "Geländer" oligomers, to study structure-property relationships in secondary structures. These compounds provide insights into helix formation and stability, advancing supramolecular chemistry.

Keywords:
atropisomerismchiralityconformation analysishelical structuresoligomers

More Related Videos

Construction and Systematical Symmetric Studies of a Series of Supramolecular Clusters with Binary or Ternary Ammonium Triphenylacetates
06:35

Construction and Systematical Symmetric Studies of a Series of Supramolecular Clusters with Binary or Ternary Ammonium Triphenylacetates

Published on: February 15, 2016

8.6K
Preparation of a Corannulene-functionalized Hexahelicene by CopperI-catalyzed Alkyne-azide Cycloaddition of Nonplanar Polyaromatic Units
09:35

Preparation of a Corannulene-functionalized Hexahelicene by CopperI-catalyzed Alkyne-azide Cycloaddition of Nonplanar Polyaromatic Units

Published on: September 18, 2016

12.2K

Related Experiment Videos

Last Updated: Mar 30, 2026

Self-assembling Morphologies Obtained from Helical Polycarbodiimide Copolymers and Their Triazole Derivatives
09:22

Self-assembling Morphologies Obtained from Helical Polycarbodiimide Copolymers and Their Triazole Derivatives

Published on: February 7, 2017

8.3K
Construction and Systematical Symmetric Studies of a Series of Supramolecular Clusters with Binary or Ternary Ammonium Triphenylacetates
06:35

Construction and Systematical Symmetric Studies of a Series of Supramolecular Clusters with Binary or Ternary Ammonium Triphenylacetates

Published on: February 15, 2016

8.6K
Preparation of a Corannulene-functionalized Hexahelicene by CopperI-catalyzed Alkyne-azide Cycloaddition of Nonplanar Polyaromatic Units
09:35

Preparation of a Corannulene-functionalized Hexahelicene by CopperI-catalyzed Alkyne-azide Cycloaddition of Nonplanar Polyaromatic Units

Published on: September 18, 2016

12.2K

Area of Science:

  • Supramolecular Chemistry
  • Organic Chemistry
  • Structural Biology

Background:

  • Investigating the relationship between molecular structure and secondary structure expression is crucial in chemistry.
  • Developing model systems that mimic complex helical arrangements is essential for understanding their formation and properties.

Purpose of the Study:

  • To present a new set of helical model compounds, "Geländer" oligomers, for investigating structure-property correlations.
  • To explore how structural modifications influence helical arrangements and their stability.
  • To analyze racemization kinetics and barriers in these novel helical systems.

Main Methods:

  • Synthesis of four related "Geländer" oligomers using a modular precursor.
  • Characterization via X-ray diffraction (XRD) analysis and computational studies.
  • Isolation of pure enantiomers and analysis of electronic circular dichroism (ECD) spectra.

Main Results:

  • Successful synthesis and characterization of novel helical "Geländer" oligomers.
  • Demonstrated correlation between structural features (e.g., relay substitution, linkage exchange) and helical parameters (torsion, distortion).
  • Insights into racemization kinetics and barriers, with helicity assignment via in silico ECD simulations.

Conclusions:

  • The developed "Geländer" oligomers serve as effective model systems for studying helical structures.
  • Structural modifications significantly impact the helical arrangement, torsion, and stability.
  • This work provides a foundation for designing and understanding complex helical supramolecular systems.