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Phylogenetic and epidemiological analysis of measles outbreaks in Denmark, 2013 to 2014

Lasse Dam Rasmussen1, Jannik Fonager, Lisbet Krause Knudsen

  • 1Microbiological Diagnostics and Virology, Statens Serum Institut, Copenhagen, Denmark.

Euro Surveillance : Bulletin Europeen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin
|November 6, 2015
PubMed

Insights

Measles outbreaks occurred in Denmark despite vaccination efforts. Even with 80% measles-mumps-rubella (MMR) vaccine coverage, transmission persisted, posing risks to both unvaccinated and vaccinated individuals.

Area of Science:

  • Virology
  • Epidemiology
  • Public Health

Background:

  • Measles remains a global threat despite effective vaccines and public health initiatives.
  • Vaccine-preventable diseases like measles continue to impact children's health worldwide.
  • Global efforts aim for measles elimination, yet challenges persist.

Purpose of the Study:

  • To investigate measles virus transmission dynamics in Denmark.
  • To analyze measles cases and circulating genotypes during importations.
  • To assess the risk of measles infection in a population with 80% MMR vaccination coverage.

Main Methods:

  • Laboratory confirmation of measles cases using RT-PCR and IgM antibody detection.
  • Genotyping of measles viruses through sequencing to identify circulating strains.
  • Analysis of vaccination status of confirmed measles cases.

Main Results:

  • Denmark experienced 44 measles cases between 2013-2014 due to independent importations.
  • Genotypes D8 and B3 were identified in 2013 and 2014, respectively.
  • Most cases were unvaccinated (27) or received one MMR dose (7); two vaccinated adults were also infected.

Conclusions:

  • Measles virus transmission can occur in populations with 80% two-dose MMR vaccination coverage.
  • Even vaccinated individuals are at risk of measles infection when transmission is established.
  • Continued vigilance and high vaccination rates are crucial for measles control and elimination efforts.
Keywords:
Measlesepidemiologygenotypingoutbreakstransmission

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