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Comparison of Bone Tissue Elements Between Normal and Osteoarthritic Pelvic Bones in Dogs
Korakot Nganvongpanit1,2, Kittisak Buddhachat3, Janine L Brown4
1Animal Bone and Joint Research Laboratory, Department of Veterinary Biosciences and Public Health, Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai, 50100, Thailand. korakot.n@cmu.ac.th.
Biological Trace Element Research
|November 6, 2015
Summary
Physiochemical analysis of canine pelvic bones reveals distinct elemental differences in osteoarthritis (OA). Manganese (Mn) and iron (Fe) were notably higher in severe OA, suggesting their role in the disease
Area of Science:
- Veterinary Science
- Biochemistry
- Materials Science
Background:
- Osteoarthritis (OA) is a degenerative joint disease affecting bone structure.
- Physiochemical analysis of bone can elucidate the etiology of OA.
- Canine models offer insights into human OA pathophysiology.
Purpose of the Study:
- To investigate elemental composition differences in canine pelvic bones across varying OA severities.
- To identify specific elements associated with OA development and progression.
Main Methods:
- Utilized a handheld X-ray fluorescence (XRF) analyzer for elemental analysis.
- Analyzed 45 canine pelvic bones (ilium and acetabulum) categorized by OA grade (normal, mild, moderate, severe).
- Quantified percentages of elements from Magnesium (Mg) to Bismuth (Bi).
Main Results:
- Significant elemental differences (P, Ca, Mn, Ag, Cd, Sn, Sb) were observed between ilium and acetabulum in normal bone.
- Manganese (Mn) and Iron (Fe) percentages were highest in severe OA groups in both ilium and acetabulum.
- Specific heavy metals (Ag, Sn, Sb) showed increased percentages in the acetabulum of severe OA cases.
Conclusions:
- Elemental composition of canine pelvic bone varies between anatomical regions and with OA severity.
- Elevated levels of Mn and Fe in severe OA bone suggest their potential involvement in OA etiology and pathophysiology.
- Further research into Mn and Fe roles could advance OA understanding and treatment.
