Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

41.1K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
41.1K
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

4.2K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
4.2K
Synthesis and Functions of Calcitonin00:51

Synthesis and Functions of Calcitonin

5.4K
Calcitonin, a vital polypeptide hormone, regulates calcium levels within body fluids. It is released by the parafollicular cells, also known as C cells, situated in the follicular epithelium of the thyroid gland. Calcitonin responds to fluctuations in blood calcium levels and the influence of gastrointestinal hormones like gastrin and cholecystokinin.
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
5.4K
Bone Disorders01:29

Bone Disorders

7.6K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
7.6K
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

4.7K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
4.7K
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

7.2K
The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
7.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Participation in Community Gathering Places and Subsequent Care Costs in Older Adults: A 2-Year Follow-Up Study.

Journal of the American Medical Directors Association·2026
Same author

Physical activity patterns in people with haemophilia with and without arthropathy: a cross-sectional study using wearable sensors.

Thrombosis journal·2026
Same author

Gefitinib-Induced Heart Failure Confirmed by a Rechallenge in a Patient with EGFR-Mutated Lung Adenocarcinoma.

Internal medicine (Tokyo, Japan)·2026
Same author

Postbiotic Metabolites from a 31-Strain <i>Lactobacillus</i>/<i>Bifidobacterium</i> Co-Culture Attenuate DSS Colitis with Barrier- and Circadian-Linked Transcriptomic Signatures.

Biology·2026
Same author

Anti-IL-6 Receptor Antibody Suppresses Visual Dysfunction in AQP4 Peptide-Immunized Mice.

Translational vision science & technology·2026
Same author

Serum from patients with acetylcholine receptor antibody-positive myasthenia gravis triggers pathogenic changes in human myotube cells.

Journal of neuroimmunology·2026

Related Experiment Video

Updated: Mar 30, 2026

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
08:56

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Published on: April 7, 2023

1.5K

Eldecalcitol prevents endothelial dysfunction in postmenopausal osteoporosis model rats.

Kenichi Serizawa1, Kenji Yogo1, Yoshihito Tashiro1

  • 1Product Research DepartmentChugai Pharmaceutical Co., Ltd, 1-135 Komakado, Gotemba, Shizuoka 412-8513, JapanProduct Research DepartmentChugai Pharmaceutical Co., Ltd, 200 Kajiwara, Kamakura, Kanagawa 247-8530, JapanMedical Science DepartmentChugai Pharmaceutical Co., Ltd, 2-1-1 Nihonbashi-Muromachi, Chuo-ku, Tokyo 103-8324, Japan.

The Journal of Endocrinology
|November 6, 2015
PubMed
Summary

Eldecalcitol (ELD) improves endothelial function in ovariectomized (OVX) rats, protecting against cardiovascular events linked to estrogen deficiency. This vitamin D derivative enhances blood vessel health without negatively impacting bone density.

Keywords:
endothelial functionestrogen deficiencyflow-mediated dilationvitamin D

More Related Videos

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
07:12

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model

Published on: September 28, 2017

8.7K
An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
06:18

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause

Published on: August 13, 2019

13.0K

Related Experiment Videos

Last Updated: Mar 30, 2026

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
08:56

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Published on: April 7, 2023

1.5K
Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
07:12

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model

Published on: September 28, 2017

8.7K
An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
06:18

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause

Published on: August 13, 2019

13.0K

Area of Science:

  • Endocrinology
  • Cardiovascular Science
  • Pharmacology

Background:

  • Postmenopausal women face increased cardiovascular event risk due to estrogen deficiency-induced endothelial dysfunction.
  • The role of vitamin D in treating endothelial dysfunction alongside osteoporosis treatment in postmenopausal women is debated.
  • Ovariectomized (OVX) rats serve as a model for postmenopausal conditions, exhibiting endothelial dysfunction and bone loss.

Purpose of the Study:

  • To investigate the endothelial protective effects of eldecalcitol (ELD) in an ovariectomized (OVX) rat model.
  • To determine if ELD can ameliorate endothelial dysfunction while simultaneously addressing bone loss.

Main Methods:

  • Ovariectomized (OVX) rats were treated with eldecalcitol (ELD) (20 ng/kg) orally, five times weekly for 4 weeks.
  • Endothelial function was assessed by measuring flow-mediated dilation (FMD) in the femoral artery using high-resolution ultrasound.
  • Vascular expression of NOX4, nitrotyrosine, p65, nitric oxide synthase (NOS) dimer/monomer ratio, and peroxisome proliferator-activated receptor gamma (PPARγ) were analyzed.

Main Results:

  • ELD administration significantly ameliorated the reduction in FMD in OVX rats.
  • ELD inhibited increases in NOX4, nitrotyrosine, and p65, and prevented the decrease in the NOS dimer/monomer ratio in femoral arteries.
  • ELD prevented the decrease in PPARγ in femoral arteries and endothelial cells, while increasing bone mineral density without affecting bone marrow PPARγ.

Conclusions:

  • Eldecalcitol (ELD) demonstrates endothelial protective effects in OVX rats, mitigating endothelial dysfunction concurrent with bone loss prevention.
  • The protective mechanism may involve improved endothelial nitric oxide synthase (eNOS) uncoupling via an antioxidative effect.
  • Normalization of vascular peroxisome proliferator-activated receptor gamma (PPARγ)/nuclear factor-kappa B (NF-κB) signaling appears central to ELD's vascular benefits.