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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.9K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Whole Body Regeneration01:33

Whole Body Regeneration

4.6K
Regeneration is the process of restoring injured or lost tissues, organs, or body parts. While simpler organisms generally show greater ability to regenerate their whole body, few complex animals show similarly exceptional regeneration. For example, planarian flatworms have a unique regenerative potential making them a popular study organism among biologists to understand the mechanisms of whole body regeneration. Other organisms, such as hydra, also show extreme regeneration potential;...
4.6K
Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

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Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
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Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

2.2K
After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
2.2K
Tissue Transplantation01:24

Tissue Transplantation

1.2K
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
1.2K
Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

6.0K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Related Experiment Video

Updated: Mar 30, 2026

3D Magnetic Stem Cell Aggregation and Bioreactor Maturation for Cartilage Regeneration
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3D Magnetic Stem Cell Aggregation and Bioreactor Maturation for Cartilage Regeneration

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Regenerative Medicine Build-Out.

Andre Terzic1, Michael A Pfenning2, Gregory J Gores2

  • 1Mayo Clinic, Rochester, Minnesota, USA terzic.andre@mayo.edu.

Stem Cells Translational Medicine
|November 6, 2015
PubMed
Summary

Regenerative medicine offers innovative solutions for chronic diseases. Mayo Clinic

Area of Science:

  • Regenerative medicine focuses on enhancing the body's natural repair mechanisms.
  • This field drives innovation in patient management for aging populations and chronic diseases.

Background:

  • There is an urgent need to translate regenerative medicine science into practical health benefits.
  • A scalable model for regenerative medicine care requires integrated supply chains and standardized applications.

Purpose of the Study:

  • To present Mayo Clinic's blueprint for the discovery, translation, and application of regenerative medicine therapies.
  • To outline a model for accelerated adoption into the standard of care, addressing patient access, enabling platforms, and care delivery.

Main Methods:

  • Establishment of regenerative medical and surgical service lines.
  • Coordination of patient access via the Regenerative Medicine Consult Service.

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3D Microtissues for Injectable Regenerative Therapy and High-throughput Drug Screening
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A Multi-Cue Bioreactor to Evaluate the Inflammatory and Regenerative Capacity of Biomaterials under Flow and Stretch
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Related Experiment Videos

Last Updated: Mar 30, 2026

3D Magnetic Stem Cell Aggregation and Bioreactor Maturation for Cartilage Regeneration
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3D Magnetic Stem Cell Aggregation and Bioreactor Maturation for Cartilage Regeneration

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3D Microtissues for Injectable Regenerative Therapy and High-throughput Drug Screening
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  • Development of platforms including the Regenerative Medicine Biotrust and Good Manufacturing Practice facilities.
  • Leveraging dedicated interventional suites for regenerative service delivery.
  • Performance tracking using a scorecard system.

    • Main Results:

    • Mayo Clinic's roadmap exemplifies an integrated approach to regenerative medicine discovery, development, and delivery.
    • The model incorporates patient access, enabling platforms, and specialized care delivery.

    Conclusions:

    • Regenerative medicine is a leading healthcare frontier with potential solutions for incurable diseases.
    • A viable framework for implementing a regenerative medicine model of care is crucial.
    • Clinical validity and utility must be established for widespread adoption and value demonstration.