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Updated: Mar 30, 2026

Facile and Efficient Preparation of Tri-component Fluorescent Glycopolymers via RAFT-controlled Polymerization
Published on: June 19, 2015
Glycopolymers Prepared by Ring-Opening Metathesis Polymerization Followed by Glycoconjugation Using a
1Department of Chemistry, Brown University, Box H, 324 Brook Street, Providence, RI, 02912, USA.
Abstract:
We describe a protocol for the preparation of glycopolymers derived from the ring-opening polymerization of a norbornene carboxylic acid derivative. Polymerization is followed by attachment of a linker and subsequent glycoconjugation via a triazole-forming azide-alkyne click reaction. The use of a protected amine-terminating agent allows for the attachment of a probe molecule such as a fluorescein dye. The syntheses of a neutral galactopolymer as well a polyanionic poly-3-O-sulfo-galactopolymer are described.
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