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Related Experiment Videos

Maleness as risk factor for slowly progressive IDDM.

T Kobayashi1, K Nakanishi, T Sugimoto

  • 1Department of Endocrinology and Metabolism, Toranomon Hospital, Okinaka Memorial Institute for Medical Research, Tokyo, Japan.

Diabetes Care
|January 1, 1989
PubMed
Summary
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Male sex is a significant risk factor for progressive beta-cell dysfunction in adult-onset diabetes. Men with islet cell antibodies showed a faster decline in C-peptide levels and a higher rate of progression to insulin dependence compared to women.

Area of Science:

  • Endocrinology
  • Immunology
  • Diabetes Research

Background:

  • Islet cell antibodies (ICA) are markers for autoimmune processes in diabetes.
  • Non-insulin-dependent diabetes mellitus (NIDDM) can progress to insulin dependence.

Purpose of the Study:

  • To investigate the effect of sex on longitudinal changes in C-peptide immunoreactivity (CPR) response to oral glucose tolerance test (OGTT).
  • To determine if sex influences the progression of beta-cell dysfunction in ICA-positive NIDDM patients.

Main Methods:

  • Longitudinal study of 30 ICA-positive NIDDM subjects (15 men, 15 women) matched for age, diabetes duration, and treatment.
  • Assessed CPR levels via OGTT up to 48 months.
  • Monitored progression to insulin-dependent state and CPR abolition.

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Main Results:

  • Male NIDDM subjects showed a progressive decrease in CPR levels.
  • 8 of 15 men developed insulin dependence with abolished CPR, compared to only 2 women (P < .05).
  • CPR decline was less pronounced in women than in men.

Conclusions:

  • Maleness is a major risk factor for slowly progressive beta-cell dysfunction in adult-onset diabetes.
  • Sex influences the rate of beta-cell failure in ICA-positive NIDDM.
  • Further research into sex-specific diabetes progression is warranted.