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BODIPY/Nile-Red-Based Efficient FRET Pair: Selective Assay of Endoplasmic Reticulum Membrane Fluidity
Zhigang Yang1,2, Youngjin Wi3, Young-Min Yoon3
1Department of Chemistry, Korea University, Seoul, 136-701, Korea.
Chemistry, an Asian Journal
|November 6, 2015
Abstract:
We synthesized a boron-dipyrromethene (BODIPY)/Nile Red hybrid probe capable of selectively recognizing fluidity changes in the endoplasmic reticulum (ER) membrane due to its preferential localization to the ER and strong energy transfer from BODIPY to the Nile Red moiety, emitting only in nonaqueous environments. ER membrane fluidity in HepG2 cells was markedly reduced by a cell model of metabolic syndrome.
