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A Betabaculovirus-Encoded gp64 Homolog Codes for a Functional Envelope Fusion Protein
Daniel M P Ardisson-Araújo1, Fernando L Melo2, Rollie J Clem3
1Laboratory of Baculovirus, Cell Biology Department, University of Brasilia, Brasilia, DF, Brazil Division of Biology, Kansas State University, Manhattan, Kansas, USA.
Abstract:
The GP64 envelope fusion protein is a hallmark of group I alphabaculoviruses. However, the Diatraea saccharalis granulovirus genome sequence revealed the first betabaculovirus species harboring a gp64 homolog (disa118). In this work, we have shown that this homolog encodes a functional envelope fusion protein and could enable the infection and fusogenic abilities of a gp64-null prototype baculovirus. Therefore, GP64 may complement or may be in the process of replacing F protein activity in this virus lineage.
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