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Updated: Mar 30, 2026

Isolation and Enrichment of Human Adipose-derived Stromal Cells for Enhanced Osteogenesis
Published on: January 12, 2015
Periostin is critical for improving the therapeutic properties of adipocyte-derived stem cells
Theresa Chow1,2, Ian M Rogers3,4,5
1Women's and Infants' Health, Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital and University of Toronto, 60 Murray Street, Box 40, Toronto, M5T 3L9, ON, Canada.
Abstract:
Periostin is a matricellular protein that is reactivated during tissue damage and repair and has been shown to be a critical regulator of multiple biological pathways involved in the repair of tissue after myocardial infarction, peripheral vascular disease, and skin wounds. The tissue repair properties attributed to periostin make it an ideal candidate to enhance the therapeutic properties of donor cells such as mesenchymal stem cells from adipocyte tissue. In a recent article in Stem Cell Research & Therapy, Qin et al. demonstrated enhanced therapeutic properties of adipocyte-derived stem cells by genetically engineering them to express periostin.

