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Exercise as Therapy for Diabetic and Prediabetic Neuropathy
J Robinson Singleton1, A Gordon Smith2, Robin L Marcus3
1Department of Neurology, University of Utah, Salt Lake City, UT, USA. rob.singleton@hsc.utah.edu.
Current Diabetes Reports
|November 6, 2015
Summary
Diabetic neuropathy, a common complication, affects nerve fibers. Aerobic exercise and reduced inactivity show promise in improving symptoms and nerve fiber regrowth.
Area of Science:
- Neurology
- Metabolic Disorders
- Exercise Physiology
Background:
- Diabetic neuropathy is a costly complication, primarily damaging small nerve fibers.
- Hyperglycemia, obesity, dyslipidemia, and inflammation contribute to its development.
Purpose of the Study:
- To explore the efficacy of exercise and reduced inactivity in managing diabetic neuropathy.
- To identify therapeutic strategies beyond glucose control.
Main Methods:
- Review of animal models and human trials on exercise interventions.
- Analysis of the impact of reducing sedentary behavior.
Main Results:
- Aerobic exercise benefits multiple pathogenic pathways, improving neuropathy symptoms.
- Exercise promotes the regeneration of cutaneous small-diameter fibers.
- Reduced inactivity offers metabolic benefits comparable to exercise.
Conclusions:
- Combined exercise and reduced inactivity may offer sustained peripheral nerve benefits.
- These lifestyle interventions target multiple aspects of diabetic neuropathy pathogenesis.
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