Related Experiment Video
Updated: Mar 30, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Using Single-Case Experiments to Support Evidence-Based Decisions: How Much Is Enough?
1Université de Montréal, Québec, Canada marc.lanovaz@umontreal.ca.
Abstract:
For practitioners, the use of single-case experimental designs (SCEDs) in the research literature raises an important question: How many single-case experiments are enough to have sufficient confidence that an intervention will be effective with an individual from a given population? Although standards have been proposed to address this question, current guidelines do not appear to be strongly grounded in theory or empirical research. The purpose of our article is to address this issue by presenting guidelines to facilitate evidence-based decisions by adopting a simple statistical approach to quantify the support for interventions that have been validated using SCEDs. Specifically, we propose the use of success rates as a supplement to support evidence-based decisions. The proposed methodology allows practitioners to aggregate the results from single-case experiments to estimate the probability that a given intervention will produce a successful outcome. We also discuss considerations and limitations associated with this approach.
More Related Videos
07:05Operant Protocols for Assessing the Cost-benefit Analysis During Reinforced Decision Making by Rodents
Published on: September 10, 2018
20:24Characterization of Complex Systems Using the Design of Experiments Approach: Transient Protein Expression in Tobacco as a Case Study
Published on: January 31, 2014
Related Concept Videos
Case Studies
What is an Experiment?
Data Collection by Experiments
An example of the experimental method is a public...
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Controls in Experiments
Experimental Designs