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Outcomes of Clostridium difficile infection in pediatric solid organ transplant recipients

C Pant1, A Deshpande2,3, M Desai1

  • 1Division of Gastroenterology, Hepatology and Motility, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA.

Transplant Infectious Disease : an Official Journal of the Transplantation Society
|November 6, 2015
PubMed

Insights

Pediatric solid organ transplant (SOT) recipients face higher Clostridium difficile infection (CDI) risks, especially younger, sicker children. CDI increases hospital stay and costs but not mortality in these patients.

Area of Science:

  • Pediatric Gastroenterology
  • Infectious Diseases
  • Transplantation Medicine

Background:

  • Clostridium difficile infection (CDI) incidence is rising in children.
  • Pediatric solid organ transplant (SOT) recipients may have increased CDI risk due to treatments like chemotherapy and extended hospital stays.

Purpose of the Study:

  • To investigate the incidence and outcomes of CDI in pediatric SOT recipients.
  • To identify risk factors and impacts of CDI in this vulnerable population.

Main Methods:

  • Utilized data from the Healthcare Cost and Utilization Project Kids' Inpatient Database.
  • Analyzed CDI as a complicating factor in pediatric SOT recipients.

Main Results:

  • Hospitalized pediatric SOT patients exhibit elevated infection rates.
  • Younger children with comorbidities and severe illness face the highest CDI risk.
  • Renal transplant recipients showed the lowest CDI incidence compared to other organ transplants.

Conclusions:

  • CDI occurrence in pediatric SOT patients leads to longer hospitalizations and increased healthcare charges.
  • CDI is not an independent predictor of in-hospital mortality for pediatric SOT recipients.
Abstract

Keywords:
C. difficile infectionchildrenincidencetransplantation

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