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Myc coordinates transcription and translation to enhance transformation and suppress invasiveness

Ran Elkon1, Fabricio Loayza-Puch2, Gozde Korkmaz2

  • 1Division of Biological Stress Response, The Netherlands Cancer Institute, Amsterdam, The Netherlands r.agami@nki.nl r.elkon@nki.nl.

EMBO Reports
|November 6, 2015
PubMed

Insights

The proto-oncogene Myc regulates both transcription and translation, impacting cancer cell growth and metastasis. This study reveals how Myc coordinates these processes, influencing oncogenic transformation and cell migration.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • c-Myc is a proto-oncogene linked to tumor aggression and poor outcomes.
  • Myc paradoxically suppresses cell motility, invasiveness, and metastasis.
  • Myc induces protein synthesis machinery, enhancing tumor cell growth.

Purpose of the Study:

  • To investigate whether Myc activation modulates translation of specific genes beyond global protein synthesis enhancement.
  • To comprehensively analyze Myc-induced changes in gene expression at transcription, translation, and protein levels.

Main Methods:

  • Global gene expression analysis at transcription, translation, and protein levels.
  • Assessment of Myc-induced changes in protein synthesis.
  • Investigation of signaling pathways including mTOR and TGFβ.

Main Results:

  • Myc activation extensively regulates protein translation specific to transcripts.
  • A strong coordination between transcription and translation regulation was observed upon Myc modulation.
  • These responses are linked to mTOR signaling for oncogenic transformation and TGFβ for cell migration.

Conclusions:

  • Myc activation leads to transcript-specific translation regulation, not just global protein synthesis increase.
  • Coordinated regulation of transcription and translation by Myc influences cancer progression.
  • Understanding these mechanisms provides novel insights into Myc's role in cancer cells.
Keywords:
c‐Mycmetastasistranscriptional responsestransformationtranslational regulation

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