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Inflammation01:38

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The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
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Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice
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Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice

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Inflammation and preterm birth.

Monica Cappelletti1, Silvia Della Bella1, Enrico Ferrazzi1

  • 1*Division of Immunobiology, Cincinnati Children's Hospital Research Foundation, and the University of Cincinnati College of Medicine, Cincinnati, Ohio, USA; Unit of Clinical and Experimental Immunology, Humanitas Clinical and Research Center, Rozzano, Italy; and Department of Woman, Mother and Neonate, Buzzi Children's Hospital, Biomedical and Clinical Sciences School of Medicine, University of Milan, Italy.

Journal of Leukocyte Biology
|November 6, 2015
PubMed
Summary
This summary is machine-generated.

Infection and inflammation are major risk factors for preterm birth, the leading cause of newborn mortality. Further research is needed to understand the specific triggers and immune pathways involved in this pregnancy complication.

Keywords:
Toll-like receptorscytokinesinfectioninnate immune cells

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Area of Science:

  • Reproductive immunology
  • Perinatal medicine
  • Infectious disease

Background:

  • Preterm birth is a leading cause of neonatal morbidity and mortality.
  • Infection and inflammation are significant risk factors for preterm birth.
  • The precise infectious agents, molecular triggers, and immune pathways remain largely unknown.

Purpose of the Study:

  • To review current clinical and animal model data on infection-induced inflammation and preterm birth.
  • To identify critical knowledge gaps in understanding the immune response to infection during pregnancy.
  • To guide future research on the pathogenesis of infection-associated preterm birth.

Main Methods:

  • Literature review of clinical studies.
  • Analysis of data from animal models of infection-induced preterm birth.
  • Synthesis of findings on immune pathways and molecular triggers.

Main Results:

  • Infection and inflammation are strongly linked to preterm birth.
  • Existing data highlight the complexity of immune responses in pregnancy.
  • Significant gaps remain in defining specific causative agents and mechanisms.

Conclusions:

  • Understanding the interplay between infection, inflammation, and preterm birth is crucial.
  • Further investigation into immune pathways is warranted.
  • Targeted research is needed to address the knowledge gaps in preterm birth pathogenesis.