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Interleukin-1 Gene Polymorphisms and their Relation with NFκB Expression and Histopathological Features in Psoriasis.

Nikhil Moorchung1, Biju Vasudevan1, Manas Chatterjee1

  • 1Department of Pathology and Dermatology, Armed Forces Medical College and Command Hospital, Pune, Maharashtra, India.

Indian Journal of Dermatology
|November 6, 2015
PubMed
Summary

Genetic variations in IL-1, specifically IL-1β and IL-1 receptor antagonist (IL-1RA), are linked to psoriasis severity through their interaction with NFκB. These IL-1 gene polymorphisms influence NFκB activation, impacting the inflammatory disease.

Keywords:
Genetic polymorphismsIL-1histopathologypsoriasis

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