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De Novo Histoid Leprosy.

Pooja Pandey1, Mavinrkainahalli Srinivasa Murthy Suresh1, Vivek Kumar Dey1

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This study presents a rare case of histoid leprosy, a distinct form of leprosy, in an elderly male without prior treatment. The patient exhibited sudden onset of dome-shaped skin lesions characteristic of histoid leprosy.

Keywords:
Histoid leprosyMulti drug therapyde novo

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Area of Science:

  • Dermatology
  • Infectious Diseases
  • Microbiology

Background:

  • Histoid leprosy is an uncommon leprosy variant with distinct clinical and histopathological features.
  • Histoid lepromas often present as sudden eruptions of dome-shaped lesions.
  • This condition is typically linked to dapsone resistance or can arise de novo.

Purpose of the Study:

  • To report a unique case of histoid leprosy presenting for the first time in an elderly male.
  • To highlight the occurrence of histoid leprosy in the post-leprosy elimination era without a history of prior treatment.
  • To describe the clinical presentation of histoid features in a novel case.

Main Methods:

  • Clinical case presentation and description.
  • Histopathological examination of skin lesions.
  • Bacteriological assessment for Mycobacterium leprae.

Main Results:

  • The patient, an elderly male, presented with no prior history of dapsone or antileprosy treatment.
  • He exhibited a sudden eruption of small to large dome-shaped lesions on normal skin.
  • The presentation was consistent with histoid features of leprosy.

Conclusions:

  • Histoid leprosy can manifest de novo, even in the post-leprosy elimination era.
  • This case underscores the importance of recognizing histoid leprosy as a distinct entity, irrespective of prior treatment history.
  • Further research into the pathogenesis and management of dapsone-naive histoid leprosy is warranted.