Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

3.4K
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
3.4K
Myasthenia Gravis: Diagnostic Tests01:15

Myasthenia Gravis: Diagnostic Tests

3.1K
Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
3.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hemorrhage, Fistulization, and Rupture: Management of a Cascade of Complications from a Single Pancreatic Pseudocyst.

Cureus·2026
Same author

Electrodiagnostic Studies as a Diagnostic and Prognostic Tool in Acute Flaccid Myelitis.

Muscle & nerve·2026
Same author

Optimizing YouTube for Medical Education: An Analysis of Popular Cardiovascular United States Medical Licensing Examination (USMLE) Step 1 Videos.

Cureus·2026
Same author

Therapeutic Advances in Non-Small Cell Lung Cancer Harboring <i>EGFR</i> Exon 20 Insertion Mutations: From Molecular Biology to Targeted Therapy.

International journal of molecular sciences·2026
Same author

Assessing High-Affinity <i>N</i>-Glycoforms of the Human Fcγ Receptor IIIa (CD16a) via Parallel Reaction Monitoring Mass Spectrometry.

Journal of proteome research·2026
Same author

Experience with Cervical Cancer Screening and Views on HPV Self-Sampling Among Somali American Women.

Journal of general internal medicine·2025

Related Experiment Video

Updated: Mar 30, 2026

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4
09:29

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4

Published on: August 21, 2017

12.1K

Multisystem involvement in neuromyelitis optica.

Megan M Langille1, Jay Desai1

  • 1Division of Neurology, Children's Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, California, USA.

Annals of Indian Academy of Neurology
|November 6, 2015
PubMed
Summary
This summary is machine-generated.

This case study details a pediatric neuromyelitis optica (NMO) patient with unusual muscle and lung involvement. It highlights the importance of recognizing multisystemic manifestations in pediatric NMO beyond the central nervous system.

Keywords:
AdenopathyNMOhyperCKemialung consolidationneuromyelitis optica

More Related Videos

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients
12:23

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients

Published on: April 14, 2014

14.7K
Human Serum Anti-aquaporin-4 Immunoglobulin G Detection by Cell-based Assay
05:45

Human Serum Anti-aquaporin-4 Immunoglobulin G Detection by Cell-based Assay

Published on: April 5, 2019

24.3K

Related Experiment Videos

Last Updated: Mar 30, 2026

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4
09:29

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4

Published on: August 21, 2017

12.1K
Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients
12:23

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients

Published on: April 14, 2014

14.7K
Human Serum Anti-aquaporin-4 Immunoglobulin G Detection by Cell-based Assay
05:45

Human Serum Anti-aquaporin-4 Immunoglobulin G Detection by Cell-based Assay

Published on: April 5, 2019

24.3K

Area of Science:

  • Neurology
  • Immunology
  • Pediatrics

Background:

  • Neuromyelitis Optica (NMO) is a rare autoimmune disorder primarily affecting the central nervous system.
  • Pediatric NMO cases are less common and may present with atypical symptoms.

Observation:

  • A pediatric patient presented with area postrema syndrome and optic neuritis.
  • Recurrent hyperCKemia (elevated creatine kinase) was observed, responding to corticosteroid treatment.
  • The patient also developed axillary and hilar adenopathy with pulmonary consolidation.

Findings:

  • The case demonstrates significant multisystemic involvement in pediatric NMO, including muscle and pulmonary manifestations.
  • Non-infectious pulmonary consolidation and adenopathy were noted, responding to immunomodulatory therapy.
  • This presentation expands the known spectrum of NMO in the pediatric population.

Implications:

  • This case underscores the need for a broader diagnostic consideration of NMO in children presenting with complex neurological and systemic symptoms.
  • Recognizing non-infectious pulmonary involvement in pediatric NMO is crucial for timely and appropriate management.
  • Further research into the pathogenesis and clinical spectrum of pediatric NMO is warranted.